Synthesis and Biological Activity of Some Novel Derivatives of 4-[5-(2,3-Dihydrobenzo[b][1,4]dioxin-7-yl)isoxazole-3-yl]benzoic Acid

摘要

Some novel isoxazole derivatives of 4-[5-(2,3-dihydrobenzo[b][1,4]dioxin-7-yl)isoxazole-3-yl]benzoic acid bearing biologically active pharmacophores like benzodioxane and peptide bond have been synthesized, and their structures are supported by FTIR,H-1 and(13)C NMR, and mass spectra. The title compounds have been tested for antimicrobial and antioxidant activities. Molecular docking of the structures has also been carried out with proteinSortase A,according to which some compounds are characterized as potentially antimicrobial agents.Four products demonstrate strong antioxidant activity.