首页> 外国专利> MANUFACTURE OF PYRIDINE-2,3-DICARBOXYLIC ACID DERIVATIVES, NOVEL 1-AMINO-1,2,3,4- TETRAHYDROPYRIDINE-2,3-DICARBOXYLIC ACID DERIVATIVE AND 1,4-DIHYDROPYRIDINE-2,3-DICARBOXYLIC ACID DERIVATIVE

MANUFACTURE OF PYRIDINE-2,3-DICARBOXYLIC ACID DERIVATIVES, NOVEL 1-AMINO-1,2,3,4- TETRAHYDROPYRIDINE-2,3-DICARBOXYLIC ACID DERIVATIVE AND 1,4-DIHYDROPYRIDINE-2,3-DICARBOXYLIC ACID DERIVATIVE

机译:吡啶-2,3-二羧酸衍生物的合成,新型1-氨基-1,2,3,4-四氢吡啶-2,3-二羧酸衍生物和1,4-二吡啶-2,3-二羧酸衍生物

摘要

A process for producing pyridine-2,3-dicarboxylic acid derivatives of the formula IMAGE (I) is described. The process is based on the cleavage of HNR10R11 from 1-amino-1,2,3,4-tetrahydropyridine-2,3-dicarboxylic acid derivatives of the formula II IMAGE (II) to give 1,4-dihydropyridine-2,3-dicarboxylic acid derivatives of the formula III IMAGE (III) and subsequent oxidation of these compounds to obtain pyridine-2,3-dicarboxylic acid derivatives of the formula I. According to one variant of the process, the 1,4-dihydropyridine-2,3-dicarboxylic acid derivatives of the formula III are obtained directly, without isolation of the intermediately formed 1-amino-1,2,3,4-tetrahydropyridine-2,3-dicarboxylic acid derivatives of the formula II, by reaction of alpha , beta -unsaturated hydrazones of the formula IV IMAGE (IV) with ethene-1,2-dicarboxylic acid derivatives of the formula V IMAGE (V) and subsequently oxidized to pyridine-2,3-dicarboxylic acid derivatives of the formula I. In the above formulae, R1, R2, R3, R4, R5, R10 and R11 have the meanings defined in claim 1. The pyridine-2,3-dicarboxylic acid derivatives of the formula I are intermediates for producing herbicidal active substances.
机译:描述了制备式(I)的吡啶-2,3-二羧酸衍生物的方法。该方法基于从式II (II)的1-氨基-1,2,3,4-四氢吡啶-2,3-二羧酸衍生物裂解HNR10R11,得到1,4-二氢吡啶-2式III (III)的1,3-二羧酸衍生物,然后将这些化合物氧化,得到式I的吡啶-2,3-二羧酸衍生物。根据该方法的一种变化,所述1,4无需分离中间体形成的式II的1-氨基-1,2,3,4-四氢吡啶-2,3-二羧酸衍生物,直接获得式III的-二氢吡啶-2,3-二羧酸衍生物,通过使式IV (IV)的α,β-不饱和与式V (V)的乙烯-1,2-二羧酸衍生物反应,然后氧化为吡啶-2,3-二羧酸在上式中,R 1,R 2,R 3,R 4,R 5,R 10和R 11具有权利要求1所定义的含义。式I的吡啶-2,3-二羧酸衍生物是用于生产除草活性物质的中间体。

著录项

  • 公开/公告号JPS6147482A

    专利类型

  • 公开/公告日1986-03-07

    原文格式PDF

  • 申请/专利权人 CIBA GEIGY AG;

    申请/专利号JP19850172542

  • 发明设计人 ADORIAN BUARUDONAA;

    申请日1985-08-07

  • 分类号C07D211/90;C07D213/79;C07D213/803;C07D213/81;C07D471/04;C07D491/048;

  • 国家 JP

  • 入库时间 2022-08-22 07:43:49

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