Dual base editor catalyzes both cytosine and adenine base conversions in human cells

Zhang Xiaohui; Zhu Biyun; Chen Liang; Xie Ling; Yu Weishi; Wang Ying; Li Linxi; Yin Shuming; Yang Lei; Hu Handan; Han Honghui; Li Yongmei; Wang Liren; Chen Geng; Ma Xueyun; Geng Hongquan; Huang Wanfeng; Pang Xiufeng; Yang Zuozhen; Wu Yuxuan; Siwko Stefan; Kurita Ryo; Nakamura Yukio; Yang Li; Liu Mingyao; Li Dali

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Dual base editor catalyzes both cytosine and adenine base conversions in human cells

机译：双基础编辑器催化人体细胞中的胞嘧啶和腺嘌呤碱基转换

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Base editors that modify both adenine and cytosine broaden the potential applications of base editing.

机译：修饰腺嘌呤和胞嘧啶的基础编辑器拓宽了基础编辑的潜在应用。

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《Nature biotechnology》 |2020年第7期|共10页
作者
Zhang Xiaohui; Zhu Biyun; Chen Liang; Xie Ling; Yu Weishi; Wang Ying; Li Linxi; Yin Shuming; Yang Lei; Hu Handan; Han Honghui; Li Yongmei; Wang Liren; Chen Geng; Ma Xueyun; Geng Hongquan; Huang Wanfeng; Pang Xiufeng; Yang Zuozhen; Wu Yuxuan; Siwko Stefan; Kurita Ryo; Nakamura Yukio; Yang Li; Liu Mingyao; Li Dali;
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East China Normal Univ Inst Biomed Sci Shanghai Key Lab Regulatory Biol Shanghai Peoples R China;

East China Normal Univ Inst Biomed Sci Shanghai Key Lab Regulatory Biol Shanghai Peoples R China;

East China Normal Univ Inst Biomed Sci Shanghai Key Lab Regulatory Biol Shanghai Peoples R China;

East China Normal Univ Inst Biomed Sci Shanghai Key Lab Regulatory Biol Shanghai Peoples R China;

East China Normal Univ Inst Biomed Sci Shanghai Key Lab Regulatory Biol Shanghai Peoples R China;

Chinese Acad Sci Univ Chinese Acad Sci Shanghai Inst Nutr &

Hlth Shanghai Inst Biol Sci CAS Key Lab Computat Biol CAS MPG Partner Inst Co Shanghai Peoples R China;

East China Normal Univ Inst Biomed Sci Shanghai Key Lab Regulatory Biol Shanghai Peoples R China;

East China Normal Univ Inst Biomed Sci Shanghai Key Lab Regulatory Biol Shanghai Peoples R China;

East China Normal Univ Inst Biomed Sci Shanghai Key Lab Regulatory Biol Shanghai Peoples R China;

East China Normal Univ Inst Biomed Sci Shanghai Key Lab Regulatory Biol Shanghai Peoples R China;

Bioray Labs Inc Shanghai Peoples R China;

East China Normal Univ Inst Biomed Sci Shanghai Key Lab Regulatory Biol Shanghai Peoples R China;

East China Normal Univ Inst Biomed Sci Shanghai Key Lab Regulatory Biol Shanghai Peoples R China;

East China Normal Univ Inst Biomed Sci Shanghai Key Lab Regulatory Biol Shanghai Peoples R China;

East China Normal Univ Inst Biomed Sci Shanghai Key Lab Regulatory Biol Shanghai Peoples R China;

Shanghai Jiao Tong Univ Xinhua Hosp Sch Med Shanghai Peoples R China;

East China Normal Univ Inst Biomed Sci Shanghai Key Lab Regulatory Biol Shanghai Peoples R China;

East China Normal Univ Inst Biomed Sci Shanghai Key Lab Regulatory Biol Shanghai Peoples R China;

Cipher Gene LLC Beijing Peoples R China;

East China Normal Univ Inst Biomed Sci Shanghai Key Lab Regulatory Biol Shanghai Peoples R China;

Texas A&

M Univ Hlth Sci Ctr Dept Mol &

Cellular Med Inst Biosci &

Technol Houston TX USA;

Japanese Red Cross Soc Blood Serv Headquarters Cent Blood Inst Dept Res &

Dev Tokyo Japan;

RIKEN Cell Engn Div BioResource Ctr Tsukuba Ibaraki Japan;

Chinese Acad Sci Univ Chinese Acad Sci Shanghai Inst Nutr &

Hlth Shanghai Inst Biol Sci CAS Key Lab Computat Biol CAS MPG Partner Inst Co Shanghai Peoples R China;

East China Normal Univ Inst Biomed Sci Shanghai Key Lab Regulatory Biol Shanghai Peoples R China;

East China Normal Univ Inst Biomed Sci Shanghai Key Lab Regulatory Biol Shanghai Peoples R China;

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中图分类普通生物学;
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专利

1. Dual base editor catalyzes both cytosine and adenine base conversions in human cells [J] . Zhang Xiaohui, Zhu Biyun, Chen Liang, Nature biotechnology . 2020,第7期

机译：双基础编辑器催化人体细胞中的胞嘧啶和腺嘌呤碱基转换
2. Targeted, random mutagenesis of plant genes with dual cytosine and adenine base editors [J] . Li Chao, Zhang Rui, Meng Xiangbing, Nature biotechnology . 2020,第7期

机译：植物基因的靶向，随机诱变与双胞组和腺嘌呤基础编辑器的植物基因
3. A dual-deaminase CRISPR base editor enables concurrent adenine and cytosine editing [J] . Grunewald Julian, Zhou Ronghao, Lareau Caleb A., Nature biotechnology . 2020,第7期

机译：双脱氨酶CRISPR基础编辑器使同时的腺嘌呤和细胞瘤编辑能够实现
4. Targeted profiling of 5-(hydroxy)methylcytosine in genomic DNA from human livers: Next-generation sequencing of target enriched DNA reveals unexpectedly high interindividual variability of cytosine methylation and hydroxymethylation [C] . Ivanov Maxim, Ingelman-Sundberg Magnus, Kals Mart, IEEE International Conference on Bioinformatics and Biomedicine . 2014

机译：人类肝脏基因组DNA中5-（羟）甲基胞嘧啶的靶向分析：富含靶DNA的下一代测序揭示了胞嘧啶甲基化和羟甲基化的意料之外的高度个体差异
5. Non-synergistic hydrogen bonding in the Watson-Crick model nucleic acid base pairs adenine-thymine and guanine-cytosine. [D] . Harris, Benjamin Leo. 1995

机译：Watson-Crick模型核酸碱基对腺嘌呤-胸腺嘧啶和鸟嘌呤-胞嘧啶中的非协同氢键。
6. Cytosine base editor 4 but not adenine base editor generates off-target mutations in mouse embryos [O] . Hye Kyung Lee, Harold E. Smith, Chengyu Liu, 2020

机译：胞嘧啶碱基编辑器4但不是腺嘌呤碱基编辑器会在小鼠胚胎中产生脱靶突变
7. Cytosine base editor 4 but not adenine base editor generates off-target mutations in mouse embryos [O] . Hye Kyung Lee, Harold E. Smith, Chengyu Liu, 2020

机译：胞嘧啶基础编辑器4但不是adenine基础编辑器在鼠标胚胎中产生脱靶突变

Dual base editor catalyzes both cytosine and adenine base conversions in human cells

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