Tumour CD274 (PD-L1) expression and T cells in colorectal cancer

Masugi Yohei; Nishihara Reiko; Yang Juhong; Mima Kosuke; da Silva Annacarolina; Shi Yan; Inamura Kentaro; Cao Yin; Song Mingyang; Nowak Jonathan A.; Liao Xiaoyun; Nosho Katsuhiko; Chan Andrew T.; Giannakis Marios; Bass Adam J.; Hodi F. Stephen; Freeman Gordon J.; Rodig Scott; Fuchs Charles S.; Qian Zhi Rong; Ogino Shuji

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Tumour CD274 (PD-L1) expression and T cells in colorectal cancer

机译：肿瘤CD274（PD-L1）表达和结直肠癌中的T细胞

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Objective Evidence suggests that CD274 (programmed death-ligand 1, B7-H1) immune checkpoint ligand repress antitumour immunity through its interaction with the PDCD1 (programmed cell death 1, PD-1) receptor of T lymphocytes in various tumours. We hypothesised that tumour CD274 expression levels might be inversely associated with T-cell densities in colorectal carcinoma tissue.

机译：目的证据表明CD274（编程死亡 - 配体1，B7-H1）免受其与各种肿瘤中T淋巴细胞的PDCD1（编程的细胞死亡1，PD-1）的相互作用抑制抗肿瘤抗扰度。我们假设肿瘤CD274表达水平可能与结肠直肠癌组织中的T细胞密度相反。

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来源
《Gut: Journal of the British Society of Gastroenterology》 |2017年第8期|共11页
作者
Masugi Yohei; Nishihara Reiko; Yang Juhong; Mima Kosuke; da Silva Annacarolina; Shi Yan; Inamura Kentaro; Cao Yin; Song Mingyang; Nowak Jonathan A.; Liao Xiaoyun; Nosho Katsuhiko; Chan Andrew T.; Giannakis Marios; Bass Adam J.; Hodi F. Stephen; Freeman Gordon J.; Rodig Scott; Fuchs Charles S.; Qian Zhi Rong; Ogino Shuji;
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作者单位

Dana Farber Canc Inst Dept Med Oncol Boston MA 02115 USA;

Dana Farber Canc Inst Dept Med Oncol Boston MA 02115 USA;

Dana Farber Canc Inst Dept Med Oncol Boston MA 02115 USA;

Dana Farber Canc Inst Dept Med Oncol Boston MA 02115 USA;

Dana Farber Canc Inst Dept Med Oncol Boston MA 02115 USA;

Dana Farber Canc Inst Dept Med Oncol Boston MA 02115 USA;

Japanese Fdn Canc Res Canc Inst Div Pathol Tokyo Japan;

Harvard Med Sch Boston MA 02115 USA;

Harvard Med Sch Boston MA 02115 USA;

Brigham &

Womens Hosp Div MPE Mol Pathol Epidemiol Dept Pathol 450 Brookline Ave DFCI Room M422;

Dana Farber Canc Inst Dept Med Oncol Boston MA 02115 USA;

Sapporo Med Univ Dept Gastroenterol Rheumatol &

Clin Immunol Sch Med Sapporo Hokkaido Japan;

Harvard Med Sch Boston MA 02115 USA;

Dana Farber Canc Inst Dept Med Oncol Boston MA 02115 USA;

Dana Farber Canc Inst Dept Med Oncol Boston MA 02115 USA;

Dana Farber Canc Inst Dept Med Oncol Boston MA 02115 USA;

Dana Farber Canc Inst Dept Med Oncol Boston MA 02115 USA;

Harvard Med Sch Boston MA 02115 USA;

Dana Farber Canc Inst Dept Med Oncol Boston MA 02115 USA;

Dana Farber Canc Inst Dept Med Oncol Boston MA 02115 USA;

Brigham &

Womens Hosp Div MPE Mol Pathol Epidemiol Dept Pathol 450 Brookline Ave DFCI Room M422;

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正文语种 eng
中图分类消化系及腹部疾病;
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专利

1. Tumour CD274 (PD-L1) expression and T cells in colorectal cancer [J] . Masugi Yohei, Nishihara Reiko, Yang Juhong, Gut: Journal of the British Society of Gastroenterology . 2017,第8期

机译：肿瘤CD274（PD-L1）表达和结直肠癌中的T细胞
2. Prognostic implication of CD274 (PD-L1) protein expression in tumor-infiltrating immune cells for microsatellite unstable and stable colorectal cancer [J] . Lee Kyu Sang, Kwak Yoonjin, Ahn Soyeon, Cancer immunology, immunotherapy : . 2017,第7期

机译：CD274（PD-L1）蛋白表达对微卫星不稳定且稳定结直肠癌的肿瘤浸润免疫细胞蛋白表达的预后意蕴
3. Clinical significance of programmed death 1 ligand-1 (CD274/PD-L1) and intra-tumoral CD8+ T-cell infiltration in stage II–III colorectal cancer [J] . Chih-Yang Huang, Shu-Fen Chiang, Tao-Wei Ke, Scientific reports. . 2018,第1期

机译：编程死亡1配体-1（CD274 / PD-L1）的临床意义和III阶段结直肠癌中的肿瘤内CD8 + T细胞浸润
4. The tumour microenvironment regulates components of the fucose biosynthesis pathways in colorectal cancer cells [C] . V. LIFSHITZ, L. CHEN-LEVI, A. ZIPIN-ROITMAN, Falk Symposium . 2007

机译：肿瘤微环境调节结直肠癌细胞中岩藻糖生物合成途径的组分
5. Immune Checkpoints PD-1/PD-L1 and Natural Killer Cells in Chemo-resistant Colorectal Cancer [D] . Siu, Hon Lam Elaine. 2019

机译：免疫检查点PD-1 / PD-L1和化疗结直肠癌中的天然杀伤细胞
6. Tumour CD274 (PD-L1) expression and T cells in colorectalcancer [O] . Yohei Masugi, Reiko Nishihara, Juhong Yang, -1

机译：大肠中肿瘤CD274（PD-L1）表达和T细胞癌症
7. Clinical significance of programmed death 1 ligand-1 (CD274/PD-L1) and intra-tumoral CD8+ T-cell infiltration in stage II–III colorectal cancer [O] . Chih-Yang Huang, Shu-Fen Chiang, Tao-Wei Ke, 2018

机译：编程死亡1配体-1（CD274 / PD-L1）的临床意义和III阶段结直肠癌中的肿瘤内CD8 + T细胞浸润

Tumour CD274 (PD-L1) expression and T cells in colorectal cancer

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