The impact of intra-operative sufentanil dosing on post-operative pain, hyperalgesia and morphine consumption after cardiac surgery.

摘要

There is an ongoing debate whether opioids when used for intra-operative analgesia may enhance post-operative pain. We studied the effect of two different intra-operative dosings of sufentanil on post-operative morphine consumption, pain and hyperalgesia after cardiac anaesthesia.Forty-two male patients (age: 48-74 years) undergoing first-time coronary artery bypass graft surgery were randomized to one of two groups receiving total intravenous anaesthesia with propofol and a target controlled infusion of sufentanil with a target of 0.4?ng/mL (group SL, n?=?20) or 0.8?ng/mL (group SH, n?=?22) plasma concentration. Post-operative morphine requirement in the first 48?h was assessed using patient-controlled analgesia (PCA). Pain rating during deep inspiration, and the extent of primary and secondary hyperalgesia near the sternotomy wound were assessed.The post-operative morphine requirements in the first 48?h were 0.68?±?0.21?mg/kg in group SL and 0.96?±?0.44?mg/kg in group SH (p?