Association of APOBEC3 deletion with cancer risk: A meta‐analysis of 26?225 cases and 37?201 controls

摘要

Abstract Previous studies have found inconsistent results regarding gene deletion in APOBEC3 (apolipoprotein B mRNA‐editing catalytic polypeptide‐like 3) and risk of cancer. We conducted a meta‐analysis of all eligible case–control studies to find out the associations between APOBEC3 deletion and cancer risk by pooling the odds ratios (ORs) and corresponding 95% confidence intervals (CIs). Overall, the findings from 20 studies (13 articles) involving of a total of 26?225 cases and 37?201 controls revealed that DD genotype was associated significantly with increased cancer risk compared to II genotype (OR?=?1.25, 95% CI?=?1.01–1.56, P ?=?0.04). Stratified analysis from 10 studies including 14?757 cases and 17?930 controls revealed that I/D variant significantly increased the risk of breast cancer in heterozygous codominant (OR?=?1.15, 95% CI?=?1.03–1.28, P ?=?0.02, ID vs II), dominant (OR?=?1.15, 95% CI?=?1.01–1.31, P ?=?0.03, ID?+?DD vs II), overdominant (OR?=?1.11, 95% CI?=?1.05–1.25, P ??0.0001, ID vs DD?+?II) and allele (OR?=?1.15, 95% CI?=?1.13–1.25, P ?=?0.03, D vs I) inheritance models. In conclusion, the data propose that APOBEC3 deletion is significantly associated with increased susceptibility to cancer in overall and breast cancer. Our findings require well‐designed replication in a larger independent genetic association study with larger sample sizes in diverse ethnicities.