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Transcutaneous oxygen pressure as a predictor for short-term survival in patients with type 2 diabetes and foot ulcers: a comparison with ankle–brachial index and toe blood pressure

机译:经皮氧压力作为2型糖尿病和足部溃疡的患者短期存活的预测因子:与踝臂指数和脚趾血压进行比较

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Aims Ankle–brachial index (ABI) is the most commonly used test when diagnosing peripheral vascular disease and is considered a marker for cardiovascular risk. Transcutaneous oxygen pressure (TcPO~(2)), a test associated with microvascular function, has in several studies shown better correlation with diabetic foot ulcer (DFU) healing. Whether a low TcPO~(2)could be a marker for mortality in the high-risk population of DFU patients has not been evaluated before. The aim of this study was to evaluate the predictive value of TcPO~(2)in comparison with ABI and toe blood pressure (TBP) on 1-year mortality in type 2 diabetes patients with DFU. Methods Type 2 diabetes patients aged?≤?90?years, with one DFU who attended our multidisciplinary DFU-unit during year 2013–2015 and were screened with TcPO~(2), ABI and TBP were retrospectively evaluated. One-year mortality was assessed from the national death register in Sweden. Results A total of 236 patients (30% women) with a median age of 76 (69–82) years were evaluated in this study. Within 1?year, 14.8% of the patients died. TcPO~(2)?
机译:AIMS Ankle-BriChial指数(ABI)是诊断外周血管疾病时最常用的测试,并且被认为是心血管风险的标志物。经皮氧压力(TCPO〜(2)),与微血管功能相关的试验,在几项研究中表现出与糖尿病足溃疡(DFU)愈合的更好相关性。如果低TCPO〜(2)可能是DFU患者的高风险群体中的死亡率是否尚未评估。本研究的目的是评估TCPO〜(2)的预测值与ABI和脚趾血压(TBP)对2型糖尿病患者DFU患者的1年死亡率相比。方法2型糖尿病患者患者≤≤90.年代,其中一年的DFU在2013 - 2015年期间参加了多学科DFU单元,并用TCPO〜(2),回顾性评估了ABI和TBP。从瑞典的国家死亡登记册评估了一年的死亡率。结果在本研究中评估了总共236名患者(30%妇女)76岁(69-82)岁的年龄为76岁(69-82)。在1年内,14.8%的患者死亡。 TCPO〜(2)?<?25?mmHg与TCPO〜(2)相比较高的1年死亡率有关?≥?25?mmHg(27.7与11.6%,p?= 0.003)。 TBP和ABI没有显着影响1年死亡率。在调整混凝剂的COX回归分析中,TCPO〜(2)独立地预测1年的死亡率,危险比对于TCPO〜(2)?<?25?mmHg 2.8(95%CI 1.34-5.91,P?= ?0.006)。结论本研究表明,低TCPO〜(2)是2型糖尿病和DFU患者的1年死亡率的独立预后标志物。

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