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Small gold nanorods-loaded hybrid albumin nanoparticles with high photothermal efficacy for tumor ablation

机译:肿瘤消融的小型金纳泊型加载杂交白蛋白纳米粒子,具有高光热功效

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摘要

Photothermal therapy using gold nanorods (AuNRs) has gained great attention for cancer therapy because AuNRs emit heat and induce tumor cell death responding to the near infrared light. However, the anticancer efficiency of AuNRs alone is undermined by its poor in vivo stability and potential toxicity. The prime purpose of this study was to send more AuNRs into tumors to more fully ablate them. For this, we fabricated hybrid albumin nanoparticles encapsulating small AuNRs (AuNRs-Alb-NPs), which take advantage of biocompatible albumin as a carrier, with better tumor targetability and high in vivo photothermal activity. The sizes of length/width of AuNRs were approximately 20.5 nm and 4.6 nm, respectively, showing a 4.5 aspect ratio, and the size of the resulting AuNRs-Alb-NPs was (similar to)130 nm, all of which are favorable for glomerular filtration and passive tumor targeting via extravasation. We chose the best formulation for AuNRs-Alb-NPs by in vitro cytotoxicity based on photothermal conversion efficiency considering the incorporated number of AuNRs. Visualized by a photo thermal camera, the local tumor temperature of mice treated with AuNRs-Alb-NPs increased to 57 degrees C, which was sufficient for the hyperthermal effect with 808 nm laser irradiation. Subsequently, AuNRs-Alb-NPs displayed remarkably better tumor ablation vs. nave formulation of AuNRs (tumor volume: 73.8 +/- 105.8 vs. 1455.3 +/- 310.4 mm(3) at day 8) in the glioblastoma N2a tumor-bearing mice. Most of all, we demonstrated, using photoacoustic imaging and inductively coupled plasma mass spectrometry, that this much better tumor ablation was due to enhanced tumor targeting with albumin nanoparticles. We believe our AuNRs-Alb-NPs should be considered promising photothermal agents that are safer, have good targetability, and exhibit excellent tumor ablation.
机译:使用Gold Nanorods(AUNR)的光热疗治疗对癌症治疗产生了很大的关注,因为AUNRS发出热量并诱导肿瘤细胞死亡响应近红外光。然而,单独的AUNR的抗癌效率受到体内稳定性和潜在毒性的贫困性而受到破坏。本研究的主要目的是将更多的AUNR送入肿瘤,以更完全消融它们。为此,我们制造了包封的杂种白蛋白纳米颗粒包封的小AUNR(AUNRS-ALB-NPS),其利用生物相容性白蛋白作为载体,具有更好的肿瘤靶向和高的体内光热活性。 AUNR的长度/宽度的尺寸分别为20.5nm和4.6nm,显示4.5纵横比,并且所得的aunrs-alb-nps的尺寸(类似于)130nm,所有这些都是有利于肾小球的过滤和通过外渗靶向的被动肿瘤。考虑到掺入掺入的AUNR的光热转换效率,我们通过体外细胞毒性来选择最佳的AUNRS-ALB-NPS。由光热相机可视化,用AUNRS-ALB-NPS处理的小鼠的局部肿瘤温度增加到57℃,足以具有808nm激光照射的过热效果。随后,AUNRS-ALB-NPS显示出显着更好的肿瘤消融与NAVE制剂的AUNRS(肿瘤体积:73.8 +/- 105.8,第8天在第8天在第8天)中的肿瘤瘤小鼠。大多数情况下,我们使用光声成像和电感耦合等离子体质谱法证明了这种更好的肿瘤消融是由于靶向与白蛋白纳米颗粒的增强肿瘤。我们相信我们的AUNRS-ALB-NPS应该被认为是有前途的光热试剂更安全,具有良好的疗法,表现出优异的肿瘤消融。

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