Disruption of Wnt/beta-Catenin Exerts Antileukemia Activity and Synergizes with FLT3 Inhibition in FLT3-Mutant Acute Myeloid Leukemia

Jiang Xuejie; Mak Po Yee; Mu Hong; Tao Wenjing; Mak Duncan H.; Kornblau Steven; Zhang Qi; Ruvolo Peter; Burks Jared K.; Zhang Weiguo; McQueen Teresa; Pan Rongqing; Zhou Hongsheng; Konopleva Marina; Cortes Jorge; Liu Qifa; Andreeff Michael; Carter Bing Z.

首页> 外文期刊>Clinical cancer research: an official journal of the American Association for Cancer Research >Disruption of Wnt/beta-Catenin Exerts Antileukemia Activity and Synergizes with FLT3 Inhibition in FLT3-Mutant Acute Myeloid Leukemia

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Disruption of Wnt/beta-Catenin Exerts Antileukemia Activity and Synergizes with FLT3 Inhibition in FLT3-Mutant Acute Myeloid Leukemia

机译：WNT /β-catenin的破坏施加抗血清血症活性，并在FLT3-突变体急性髓性白血病中促进FLT3抑制

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Purpose: Wnt/beta-catenin signaling is required for leukemic stern cell function. FLT3 mutations are frequently observed in acute myeloid leukemia (AML). Anomalous FTL3 signaling increases beta-catenin nuclear localization and transcriptional activity. FLT3 tyrosine kinase inhibitors (TKI) are used clinically to treat FLT3-mutated AMI patients, but with limited efficacy. We investigated the antileukeinia activity of combined Wnt/beta-catenin and 11.13 inhibition in 1'1 7 3-mutant AML.

机译：目的：白血病船只功能需要WNT /β-连环蛋白信号传导。在急性髓性白血病（AML）中经常观察到FLT3突变。异常FTL3信号传导增加β-连环蛋白核定位和转录活动。 FLT3酪氨酸激酶抑制剂（TKI）在临床上使用，以治疗FLT3突变的AMI患者，但有限的功效。我们调查了在1'17 3-突变体AML中组合的WNT /β-catenin和11.13抑制的抗血糖症活性。

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《Clinical cancer research: an official journal of the American Association for Cancer Research 》 |2018年第10期| 共13页
作者
Jiang Xuejie; Mak Po Yee; Mu Hong; Tao Wenjing; Mak Duncan H.; Kornblau Steven; Zhang Qi; Ruvolo Peter; Burks Jared K.; Zhang Weiguo; McQueen Teresa; Pan Rongqing; Zhou Hongsheng; Konopleva Marina; Cortes Jorge; Liu Qifa; Andreeff Michael; Carter Bing Z.;
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作者单位

Univ Texas MD Anderson Canc Ctr Dept Leukemia Sect Mol Hematol &

Therapy Houston TX 77030 USA;

Univ Texas MD Anderson Canc Ctr Dept Leukemia Sect Mol Hematol &

Therapy Houston TX 77030 USA;

Univ Texas MD Anderson Canc Ctr Dept Leukemia Sect Mol Hematol &

Therapy Houston TX 77030 USA;

Univ Texas MD Anderson Canc Ctr Dept Leukemia Sect Mol Hematol &

Therapy Houston TX 77030 USA;

Univ Texas MD Anderson Canc Ctr Dept Leukemia Sect Mol Hematol &

Therapy Houston TX 77030 USA;

Univ Texas MD Anderson Canc Ctr Dept Leukemia Sect Mol Hematol &

Therapy Houston TX 77030 USA;

Univ Texas MD Anderson Canc Ctr Dept Leukemia Sect Mol Hematol &

Therapy Houston TX 77030 USA;

Univ Texas MD Anderson Canc Ctr Dept Leukemia Sect Mol Hematol &

Therapy Houston TX 77030 USA;

Univ Texas MD Anderson Canc Ctr Dept Leukemia Sect Mol Hematol &

Therapy Houston TX 77030 USA;

Univ Texas MD Anderson Canc Ctr Dept Leukemia Sect Mol Hematol &

Therapy Houston TX 77030 USA;

Univ Texas MD Anderson Canc Ctr Dept Leukemia Sect Mol Hematol &

Therapy Houston TX 77030 USA;

Univ Texas MD Anderson Canc Ctr Dept Leukemia Sect Mol Hematol &

Therapy Houston TX 77030 USA;

Univ Texas MD Anderson Canc Ctr Dept Leukemia Sect Mol Hematol &

Therapy Houston TX 77030 USA;

Univ Texas MD Anderson Canc Ctr Dept Leukemia Sect Mol Hematol &

Therapy Houston TX 77030 USA;

Univ Texas MD Anderson Canc Ctr Dept Leukemia Houston TX 77030 USA;

Southern Med Univ Nanfang Hosp Dept Hematol Guangzhou Guangdong Peoples R China;

Univ Texas MD Anderson Canc Ctr Dept Leukemia Sect Mol Hematol &

Therapy Houston TX 77030 USA;

Univ Texas MD Anderson Canc Ctr Dept Leukemia Sect Mol Hematol &

Therapy Houston TX 77030 USA;

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正文语种 eng
中图分类肿瘤学 ;
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1. Disruption of Wnt/beta-Catenin Exerts Antileukemia Activity and Synergizes with FLT3 Inhibition in FLT3-Mutant Acute Myeloid Leukemia [J] . Jiang Xuejie, Mak Po Yee, Mu Hong, Clinical cancer research: an official journal of the American Association for Cancer Research . 2018 ,第10期

机译：WNT /β-catenin的破坏施加抗血清血症活性，并在FLT3-突变体急性髓性白血病中促进FLT3抑制
2. Combined inhibition of PI3K delta and FLT3 signaling exerts synergistic antitumor activity and overcomes acquired drug resistance in FLT3-activated acute myeloid leukemia [J] . He Ye, Sun Liping, Xu Yongping, Cancer letters . 2018 ,第期

机译：PI3Kδ和FLT3信号传导的组合抑制施加协同抗肿瘤活性，克服FLT3活性急性髓性白血病中获得的耐药性
3. Inhibition of EZH2 by chidamide exerts antileukemia activity and increases chemosensitivity through Smo/Gli-1 pathway in acute myeloid leukemia [J] . Xuejie Jiang, Ling Jiang, Jiaying Cheng, Journal of Translational Medicine . 2021 ,第1期

机译：赤酰胺抑制EZH2施加抗血清血症活性，并通过急性髓性白血病中的Smo / Gli-1途径增加化学敏感性
4. An Integrated Approach of Gene Expression and DNA-methylation Profiles of WNT Signaling Genes Uncovers Novel Prognostic Markers in Acute Myeloid Leukemia [C] . Erdogan Taskesen, Prank J.T. Staal, Marcel J.T. R.einders PRIB 2014. . 2014

机译：基因表达的综合方法和WNT信号传导基因的DNA-甲基化谱揭示急性髓性白血病中的新型预后标志物
5. Comparison of FLT3 Inhibitors with the Standard Treatment for FLT3-ITD Mutated Acute Myeloid Leukemia [D] . Argetsinger, Stephanie. 2018

机译：FLT3抑制剂对FLT3-ITD突变急性髓性白血病标准治疗的比较
6. Disruption of Wnt/β-catenin exerts anti-leukemia activity and synergizes with FLT3 inhibition in FLT3-mutant acute myeloid leukemia [O] . Xuejie Jiang, Po Yee Mak, Hong Mu, -1

机译：Wnt /β-catenin的破坏发挥抗白血病活性并与FLT3突变的急性髓细胞白血病中的FLT3抑制协同作用。
7. Disruption of Wnt/β-Catenin Exerts Antileukemia Activity and Synergizes with FLT3 Inhibition in FLT3-Mutant Acute Myeloid Leukemia [O] . Xuejie Jiang, Po Yee Mak, Hong Mu, 2018

机译：Wnt /β-catenin的破坏施加抗血血症活性，并在FLT3-突变体急性髓性白血病中促进FLT3抑制促进

Disruption of Wnt/beta-Catenin Exerts Antileukemia Activity and Synergizes with FLT3 Inhibition in FLT3-Mutant Acute Myeloid Leukemia

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