Host Lymphopenia Enhances the Abundance, Activation Status, and Antitumor Efficacy of Tumor-specific T Cells Delivered Directly into the Brain

Suryadevara Carter; Chongsathidkiet Pakawat; Desai Rupen; Abel Melissa; Elsamadicy Aladine; Woroniecka Karolina; Snyder David; Li Qi-Jing; Fecci Peter; Sanchez-Perez Luis; Sampson John

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Host Lymphopenia Enhances the Abundance, Activation Status, and Antitumor Efficacy of Tumor-specific T Cells Delivered Directly into the Brain

机译：宿主淋巴细胞增强肿瘤特异性T细胞直接进入大脑的丰度，活化状态和抗肿瘤效果

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《Journal of neurosurgery.》 |2017年第4期|共1页
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Suryadevara Carter; Chongsathidkiet Pakawat; Desai Rupen; Abel Melissa; Elsamadicy Aladine; Woroniecka Karolina; Snyder David; Li Qi-Jing; Fecci Peter; Sanchez-Perez Luis; Sampson John;
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中图分类头部及神经外科学;
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1. Host Lymphopenia Enhances the Abundance, Activation Status, and Antitumor Efficacy of Tumor-specific T Cells Delivered Directly into the Brain [J] . Suryadevara Carter, Chongsathidkiet Pakawat, Desai Rupen, Journal of neurosurgery. . 2017,第4期

机译：宿主淋巴细胞增强肿瘤特异性T细胞直接进入大脑的丰度，活化状态和抗肿瘤效果
2. Greater chemotherapy-induced lymphopenia enhances tumor-specific immune responses that eliminate EGFRvlll-expressing tumor cells in patients with glioblastoma [J] . John H. Sampson, Kenneth D. Aldape, Gary E. Archer, Neuro-Oncology . 2011,第3期

机译：更大的化学疗法诱导的淋巴细胞减少症可增强肿瘤特异性免疫反应，从而消除胶质母细胞瘤患者中表达EGFRvll1的肿瘤细胞
3. Liver X receptor activation enhances blood-brain barrier integrity in the ischemic brain and increases the abundance of ATP-binding cassette transporters ABCB1 and ABCC1 on brain capillary cells [J] . ElaliA., HermannD.M. Brain pathology . 2012,第2期

机译：肝X受体的活化增强缺血性脑的血脑屏障完整性，并增加脑毛细血管细胞上ATP结合盒转运蛋白ABCB1和ABCC1的丰度
4. Increasing the efficacy of antitumor glioma vaccines by photodynamic therapy and local injection of allogeneic glioma cells [C] . Catherine E. Christie, Qian Peng, Steen J. Madsen, Clinical and translational neurohotonics; neural imaging and sensing; and optogenetics and optical manipulation . 2016

机译：通过光动力疗法和局部注射同种异体神经胶质瘤细胞提高抗肿瘤神经胶质瘤疫苗的功效
5. Tumor-specific human primary T cells engineered to overexpress IL-2, IL-7, IL-15, or IL-21 confer varying degrees of tumor rejection and xenogeneic graft-versus-host disease in an immunodeficient mouse model. [D] . Markley, John Charles. 2009

机译：经过工程改造以过度表达IL-2，IL-7，IL-15或IL-21的肿瘤特异性人类原代T细胞可在免疫缺陷小鼠模型中赋予不同程度的肿瘤排斥反应和异种移植物抗宿主病。
6. Antitumor effector B cells directly kill tumor cells involving the CXCL12/CXCR4 pathway and their therapeutic efficacy is enhanced by IL-2 [O] . Qiao Li, Yang Xia 2015

机译：抗肿瘤效应B细胞直接杀死涉及CXCL12 / CXCR4途径的肿瘤细胞IL-2增强其治疗功效
7. IMST-44. LYMPHOPENIA ENHANCES THE EFFICACY OF CAR T CELLS DELIVERED LOCO-REGIONALLY IN THE BRAIN FOR THE TREATMENT OF GLIOBLASTOMA [O] . Carter M. Suryadevara, Rupen Desai, David J. Snyder, 2016

机译：IMST-44。淋巴细胞增强了CAR T细胞在大脑中递送了潜在地区的疗效治疗胶质母细胞瘤的疗效
8. Enhanced Eradication of Lymphoma by Tumor-Specific Cytotoxic T-Cells Secreting an Engineered Tumor-Specific Immunotoxin [R] . Yotnda, P. 2010

机译：通过肿瘤特异性细胞毒性T细胞分泌工程化肿瘤特异性免疫毒素，增强根除淋巴瘤

Host Lymphopenia Enhances the Abundance, Activation Status, and Antitumor Efficacy of Tumor-specific T Cells Delivered Directly into the Brain

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