Chromatic response of cationic polydiacetylene vesicles induced by permeation of target compound

摘要

A polydiacetylene vesicle was formed by sonication and UV irradiation of the diacetylene DPAI-bis-PCDA, which has quaternary ammonium head group. A color-changeable detection system during permeation of the target compound from inside to outside the vesicle was prepared using this vesicle. A mixed vesicle system with DPAI-bis-PCDA and dioctadecyldimethylammonium chloride (DODMAC) was used in this study. DODMAC was necessary to exhibit sufficient color change. Methotrexate and neomycin were used as target compounds, and the optimum ratio of DPAI-bis-PCDA to DODMAC for sufficient color change was determined. When MTX was used as the target compound, 6:4 was the optimum ratio, whereas it was 7:3 for neomycin.