Visible-Light-Mediated Direct Decarboxylative Acylation of Electron-Deficient Heteroarenes Using alpha-Ketoacids

摘要

Acylation of electron-deficient heteroaromatic compounds has been developed using visible light. alpha-Ketoacids have been used as an efficient source of acyl radicals under photoredox conditions. The in situ generated acyl radicals from alpha-ketoacids have been coupled to a wide variety of electron-deficient heteroaromatic compounds in a Minisci type reaction. This method would be attractive to access biologically attractive molecules.