Cobalt-catalyzed hydro-difluoromethylthiolation/hydro-trifluoromethylthiolation of unactivated alkenes

摘要

An efficient Co-catalyzed hydro-difluoromethylthiolation/hydro-trifluoromethylthiolation reaction of unactivated alkenes was described. Both reactions were conducted at room temperature and a variety of common functional groups such as halogen, ester, aldehyde, enolizable ketone or ester, nitro or cyano group, sulfonate and carbamate were compatible with the reaction conditions. Radical cyclization and radical inhibitor experiments suggested that the reaction proceeds through a free radical process. (C) 2019 Elsevier Ltd. All rights reserved.