摘要:报道了一务哌啶生物碱(-)-Deoxoprosophylline的不对称合成方法.采用二碘化钐促进的手性叔丁基甲磺亚胺10与取代醛11交叉偶联为关键技术,构筑重要中间体--反式羟甲基化β-氨基醇9的立体化学,该反应的收率为77%,立体选择性为99%.这种高选择性地合成反式羟甲基化β-氨基醇的方法可方便地应用于多种含有2-羟甲基-6-取代-3-羟基哌啶生物碱的不对称合成中.%The SmⅠ2 induced cross-coupling of chiral N-tert-butanesulfinyl imine 10 with aldehyde 11 to form hydroxymethyl-β-amino alcohol 9 (yield,77%) with high diastereoselectivity 9>99%, de) is described in this paper.It has been used as the key step for asymmetric synthesis of (-)-deoxoprosophylline 1. Moreover,our route features the formation of anti-hydroxymethyl-β-amino alcohol. which might be generally applicable in the synthesis of various 2-hydroxymethyl-6-alkylated-3-hydroxy piperidine alkaloids and their deoxygenated derivatives with structural and biological importance.
摘要:This paper is concerned with the existence of entire solutions in a vector disease model with diffusive and nonlocal delay. Here the entire solutions are meant by solutions defined for all t←R.By considering the mixing of traveling wave solutions with heteroclinic orbits of the spatially averaged ordinary differential equations,several new types of entire solutions are obtained.%研究了一类具有非局部时滞和空间扩散的传染病模型的整体解,这里整体解是指时间变量t在整个实轴R上有定义的古典解.利用方程的行波解和相应常微分方程的异宿轨道,得到了几类新型的整体解.