Synthesis,Anti-inflammatory,Analgesic and Antipyretic Activity of Novel 1,3,5-Trisubstituted Pyrazole Derivatives

摘要

A novel series of 1,3,5-trisubstituted pyrazole derivatives were synthesized by the cycloaddition reaction between the electron rich N-substituted aryl hydrazones and nitro-olefins.Different N-substituted aryl hydrazones(la-j)on reacting with 4-methyl-β-nitrostyrene(2)in ethylene glycol or trifluoroethanol-trifluoro acetic acid mixture(for acid stable hydrazones)at 120 °C,yielded various 1,3,5-trisubstituted pyrazoles(3a-j).The final products were characterized by spectral analysis using Mass,NMR and IR spectroscopy.All the products were assessed for their anti-inflammatory,analgesic and antipyretic activities on Swiss albino rats.All the compounds(3a-j)exhibited noteworthy defence against inflammation,nociception and hyperthermia.Compounds(3e and 3h)disclosed better antiinflammatory,analgesic and antipyretic activities while compound 3c had highest anti-inflammatory activity compared to the standard nimesulide.