A convenient synthesis of 1,3,4-thiadiazole and 1,3,4-oxadiazole based peptidomimetics employing diacylhydrazines derived from amino acids

G. Nagendra; Ravi S. Lamani; N. Narendra

首页> 外文期刊>Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry >A convenient synthesis of 1,3,4-thiadiazole and 1,3,4-oxadiazole based peptidomimetics employing diacylhydrazines derived from amino acids

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A convenient synthesis of 1,3,4-thiadiazole and 1,3,4-oxadiazole based peptidomimetics employing diacylhydrazines derived from amino acids

机译：使用衍生自氨基酸的二酰基肼方便地合成1,3,4-噻二唑和1,3,4-恶二唑类拟肽

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摘要

Synthesis of novel orthogonally protected 1,3,4-thiadiazole and 1,3,4-oxadiazole tethered dipeptide mimetics is described. Both the heterocycles are prepared via a set of diacylhydrazines derived from amino acids. 1,3,4-Thiadiazoles are synthesized by dehydrosulfurization using Lawesson's reagent while 1,3,4-oxadiazoles are obtained by EDC mediated cyclodehydration.

机译：描述了新型正交保护的1,3,4-噻二唑和1,3,4-恶二唑束缚的二肽模拟物的合成。两个杂环都是通过一组衍生自氨基酸的二酰基肼制备的。 1,3,4-噻二唑是通过使用Lawesson试剂进行脱硫而合成的，而1,3,4-恶二唑是通过EDC介导的环脱水获得的。

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《Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry》 |2010年第48期|共4页
作者
G. Nagendra; Ravi S. Lamani; N. Narendra;
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正文语种 eng
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关键词
Peptidomimetics; Diacylhydrazine; Cyclization; Thiadiazole; Oxadiazole;

机译：拟肽;二酰基肼;环化;噻二唑;恶二唑;

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1. A convenient synthesis of 1,3,4-thiadiazole and 1,3,4-oxadiazole based peptidomimetics employing diacylhydrazines derived from amino acids [J] . G. Nagendra, Ravi S. Lamani, N. Narendra Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry . 2010,第48期

机译：使用衍生自氨基酸的二酰基肼方便地合成1,3,4-噻二唑和1,3,4-恶二唑类拟肽
2. Synthesis of Novel 2,5-Disubstituted-1,3,4-thiadiazoles Clubbed 1,2,4-Triazole, 1,3,4-Thiadiazole, 1,3,4-Oxadiazole and/or Schiff Base as Potential Antimicrobial and Antiproliferative Agents [J] . Rezki Nadjet, Al-Yahyawi Amjad M., Bardaweel Sanaa K., Molecules . 2015,第9期

机译：新型的2,5-二取代的1,3,4-噻二唑合成了潜在的抗菌和抗增殖的棒状1,2,4-三唑，1,3,4-噻二唑，1,3,4-恶二唑和/或席夫碱代理商
3. Synthesis of Novel 2,5-Disubstituted-1,3,4-thiadiazoles Clubbed 1,2,4-Triazole, 1,3,4-Thiadiazole, 1,3,4-Oxadiazole and/or Schiff Base as Potential Antimicrobial and Antiproliferative Agents [J] . Amjad M. Al-Yahyawi, Derek J. McPhee, Fawzia F. Al-Blewi, Molecules . 2015,第9期

机译：新型的2,5-二取代的1,3,4-噻二唑合成了潜在的抗菌和抗增殖的棒状1,2,4-三唑，1,3,4-噻二唑，1,3,4-恶二唑和/或席夫碱代理商
4. The Synthesis, Crystal Structure and Self-Organization of Molecules Containing 2,5-Bis(o-amino-phenyi)-1,3,4-Oxadiazoles Unit and N-Tos-L-Amino Acid Residues [C] . Hongwu Zhao International symposium for Chinese organic chemists . 2000

机译：含有2,5-双（O-氨基 - 酚）-1,3,4-二氧化唑单元和N-TOS-L-氨基酸残基的合成，晶体结构和自组织
5. Part I: 1,3,4-oxadiazoles in tandem Diels-Alder, 1,3-dipolar cycloaddition reactions: A rapid synthesis of vinca alkaloid motifs. Part II: Exceptionally potent inhibitors of fatty acid amide hydrolase [D] . Wilkie, Gordon David 2002

机译：第一部分：串联Diels-Alder中的1,3,4-恶二唑，1,3-偶极环加成反应：长春花生物碱基序的快速合成。第二部分：脂肪酸酰胺水解酶的超强抑制剂
6. Synthesis, characterization and RHF/ab initio simulations of 2-amino-1,3,4-thiadiazole and its annulated ring junction pyrimidine derivatives [O] . Wafaa S. Hamama, Moustafa A. Gouda, Mamdouh S. Soliman, 1992

机译：2-氨基-1,3,4-噻二唑及其环状环结嘧啶衍生物的合成，表征和RHF /从头算
7. A convenient synthesis of 1,3,4-thiadiazole and 1,3,4-oxadiazole based peptidomimetics employing diacylhydrazines derived from amino acids [O] . Nagendra G., Lamani R.S., Narendra N., 2010

机译：使用氨基酸衍生的二酰基肼方便地合成1,3,4-噻二唑和1,3,4-恶二唑基肽模拟物

A convenient synthesis of 1,3,4-thiadiazole and 1,3,4-oxadiazole based peptidomimetics employing diacylhydrazines derived from amino acids

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