SYNTHESIS OF 2-(METHYL-SULFONYL)-5-(TRIFLUOROMETHYL)-1,3,4-THIADIAZOLE VIA OXIDATION OF 2-(METHYLTHIO)-5-(TRIFLUOROMETHYL)-1,3,4-THIADIAZOLE WITH GLACIAL ACETIC ACID

摘要

The present invention provides a process for making thiadiazole sulfones. The present process is used to make 2-(methylsulfonyl)-5- (trifluoromethyl)-1,3,4-thiadiazole. 2-(Methylsulfonyl)-5-(trifluoromethyl)-1,3,4-thiadiazole is made using catalytic oxidation in the presence of a suitable oxidizing agent. The catalyst used for the oxidation reaction is glacial acetic acid.