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A convenient synthesis of 1,3,4-thiadiazole and 1,3,4-oxadiazole based peptidomimetics employing diacylhydrazines derived from amino acids

机译：使用氨基酸衍生的二酰基肼方便地合成1,3,4-噻二唑和1,3,4-恶二唑基肽模拟物

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摘要

Synthesis of novel orthogonally protected 1,3,4-thiadiazole and 1,3,4-oxadiazole tethered dipeptide mimetics is described. Both the heterocycles are prepared via a set of diacylhydrazines derived from amino acids. 1,3,4-Thiadiazoles are synthesized by dehydrosulfurization using Lawesson's reagent while 1,3,4-oxadiazoles are obtained by EDC mediated cyclodehydration. Â© 2010 Elsevier Ltd. All rights reserved.

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Nagendra G.; Lamani R.S.; Narendra N.; Sureshbabu V.V.;
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1. A convenient synthesis of 1,3,4-thiadiazole and 1,3,4-oxadiazole based peptidomimetics employing diacylhydrazines derived from amino acids [J] . G. Nagendra, Ravi S. Lamani, N. Narendra Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry . 2010,第48期

机译：使用衍生自氨基酸的二酰基肼方便地合成1,3,4-噻二唑和1,3,4-恶二唑类拟肽
2. Synthesis of Heterocycles from Arylation Products of Unsaturated Compounds: XVIII.* 5-Arylfuran-2-carboxylic Acids and Their Application in the Synthesis of 1,2,4-Thiadiazole,1,3,4-Oxadiazole, and [1,2,4]Triazolo[3,4-b][1,3,4]thiadiazole Derivatives [J] . Yu. I. Gorak, N. D. Obushak, V. S. Matiichuk Russian Journal of Organic Chemistry . 2009,第4期

机译：由不饱和化合物的丙烯酸化产物合成杂环：XVIII。* 5-芳基呋喃-2-羧酸及其在1,2,4-噻二唑，1,3,4-Oxadiazole和[1,2， 4]三唑[3,4-b] [1,3,4]噻二唑衍生物
3. Synthesis of Novel 2,5-Disubstituted-1,3,4-thiadiazoles Clubbed 1,2,4-Triazole, 1,3,4-Thiadiazole, 1,3,4-Oxadiazole and/or Schiff Base as Potential Antimicrobial and Antiproliferative Agents [J] . Rezki Nadjet, Al-Yahyawi Amjad M., Bardaweel Sanaa K., Molecules . 2015,第9期

机译：新型的2,5-二取代的1,3,4-噻二唑合成了潜在的抗菌和抗增殖的棒状1,2,4-三唑，1,3,4-噻二唑，1,3,4-恶二唑和/或席夫碱代理商
4. The Synthesis, Crystal Structure and Self-Organization of Molecules Containing 2,5-Bis(o-amino-phenyi)-1,3,4-Oxadiazoles Unit and N-Tos-L-Amino Acid Residues [C] . Hongwu Zhao International symposium for Chinese organic chemists . 2000

机译：含有2,5-双（O-氨基 - 酚）-1,3,4-二氧化唑单元和N-TOS-L-氨基酸残基的合成，晶体结构和自组织
5. Part I: 1,3,4-oxadiazoles in tandem Diels-Alder, 1,3-dipolar cycloaddition reactions: A rapid synthesis of vinca alkaloid motifs. Part II: Exceptionally potent inhibitors of fatty acid amide hydrolase [D] . Wilkie, Gordon David 2002

机译：第一部分：串联Diels-Alder中的1,3,4-恶二唑，1,3-偶极环加成反应：长春花生物碱基序的快速合成。第二部分：脂肪酸酰胺水解酶的超强抑制剂
6. Synthesis, characterization and RHF/ab initio simulations of 2-amino-1,3,4-thiadiazole and its annulated ring junction pyrimidine derivatives [O] . Wafaa S. Hamama, Moustafa A. Gouda, Mamdouh S. Soliman, 1992

机译：2-氨基-1,3,4-噻二唑及其环状环结嘧啶衍生物的合成，表征和RHF /从头算
7. Synthesis of Novel 2,5-Disubstituted-1,3,4-thiadiazoles Clubbed 1,2,4-Triazole, 1,3,4-Thiadiazole, 1,3,4-Oxadiazole and/or Schiff Base as Potential Antimicrobial and Antiproliferative Agents [O] . Nadjet Rezki, Amjad M. Al-Yahyawi, Sanaa K. Bardaweel, 2015

机译：合成新的2,5-二取代-1,3,4-噻二唑俱乐部1,2,4-三唑，1,3,4-噻二唑，1,3,4-恶二唑和/或希夫碱作为潜在的抗菌和抗增殖剂代理

A convenient synthesis of 1,3,4-thiadiazole and 1,3,4-oxadiazole based peptidomimetics employing diacylhydrazines derived from amino acids

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