A perinatal nitric oxide donor increases renal vascular resistance and ameliorates hypertension and glomerular injury in adult fawn-hooded hypertensive rats

摘要

A large body of experimental and epidemiological studies supports the concept that the intrauterine and early postnatal environment interacts with early development in that it can program metabolic and cardiovascular disease (5, 18, 27). Most of these studies focus on how aberrant perinatal factors increase the occurrence of pathologies in later life. When such factors are superimposed on a specific background of inherited disease, developmental programs will also be affected.