Mechanics of the left ventricular myocardial interstitium: effects of acute and chronic myocardial edema

摘要

Models of chronic myocardial edema have been shown to induce development of myocardial interstitial fibrosis (27). Formation of left ventricular edema, after 2 mo of pulmonary artery banding in dogs, results in significantly increased interstitial collagen deposition in the myocardium of the left ventricular freewall (27). Chronic pulmonary artery banding in rats results in biventricular myocardial edema formation and increased myocardial mRNA levels of collagen types I and III within the left and right ventricular myocardium (9).