急性心肌梗死PCI术后心肌间质胶原与左心室重构关系的研究进展

摘要

The changes in the number and distribution of collagen after acute myocardial infarction ( AMI ) , causes cardiac interstitial fibrosis , limits myocardial activity, reduces ventricular compliance , ventricular structural and functional change( i. e. ventricular remodeling ). Ventricular remodeling is an important cause of heart failure, affecting AMI prognosis. Myocardial interstitial collagen metabolism can be influenced by AMI after PCI, causing the interstitial collagen content and distribution change, which effectively inhibit left ventricular remodeling after AMI and improve cardiac function. Here is to make a review on the correlation between myocardial interstitial collagen and left ventricular remodeling after PCI for AMI.%急性心肌梗死后胶原的数量及分布发生改变,引起心脏间质纤维化,限制心肌活动,降低心室的顺应性,使心室结构和功能发生改变(即心室重构).心室重构是引起心力衰竭的重要原因,影响急性心肌梗死预后.急性心肌梗死后经皮冠状动脉介入治疗术可对心肌间质胶原代谢产生影响,使间质胶原含量及分布发生变化,从而有效抑制急性心肌梗死后左心室重构,改善心功能.现就急性心肌梗死经皮冠状动脉介入治疗术后心肌间质胶原与左心室重构的关系研究予以综述.