Effect of collagen cross-linking inhibition by local application of beta-aminopropionitrile fumarate on wound contraction and healing (macroscopic study)

摘要

Wound contraction is a major component of second-intention wound healing. The mechanism of this process is not completely understood. Two theories have been described for the mechanism of the wound contraction. To evaluate the collagen cross-linking inhibition on wound contraction, the present study was carried out. Macroscopical aspects of second-intention healing of full-thickness, excisional wounds were studied in five normal male mixed-breed dogs. Under general anesthesia, two full-thickness skin wounds (20x20 mm) were created on the back of each dog symmetrically. Left-side wounds (test group) and right-side wounds (control group) were treated topically with beta-aminopropionitrile fumarate 5 mg/ml in methyl cellulose gel and methyl cellulose gel, respectively.