Integrated Analysis on Effect of Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA) on Fasting Serum Triglyceride Level in Borderline Subjects of Hyperlipidemia

摘要

Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), contained in mainly fish oil, has various physiological activities, and especially, the effect of serum triglyceride (TG) reduction is well known as strong evidence. However, study populations included healthy as well as diseased participants, and there has little data that are conducted in healthy and borderline subjects in Japanese. In this article, we report reanalysis that are conducted to divided into healthy/borderline subjects (fasting serum TG<=199 mg/dL) and mild hyperlipidemia patient (fasting serum TG>199 mg/dL), using an independent two of RCT data, those are same protocol. In the stratified analysis with individual two RCT, there are no subgroups those showed statistically significant difference. The reason for this is probably alack of power due to the decrease in the number of participants.Then we conducted two RCT data integrated analyzed using Fixed Effect Model which is used in meta-analysis, and corrected p-value for multiple comparisons by Holm-Bonferroni method. In the subgroup of healthy/borderline subjects, serum TG reduction compared with placebo are observed statistical significant in all periods.Based on this, we confirmed that the effect of EPA/DHA on serum TG reduction effect in healthy/borderline subjects. We propose to apply the integrated analyzed techniques of meta-analysis, as shown in the report, for to cover the shortage of statistical analysis power by stratified analysis.