Design and synthesis of new orally active nonpeptidic inhibitors of human neutrophil elastase.

Ohmoto K; Yamamoto T; Horiuchi T; Imanishi H; Odagaki Y; Kawabata K; Sekioka T; Hirota Y; Matsuoka S; Nakai H; Toda M; Cheronis JC; Spruce LW; Gyorkos A; Wieczorek M

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Design and synthesis of new orally active nonpeptidic inhibitors of human neutrophil elastase.

机译：设计和合成新型的人类嗜中性粒细胞弹性蛋白酶的口服非肽类抑制剂。

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来源
《Journal of Medicinal Chemistry》 |2000年第26期|共3页
作者
Ohmoto K; Yamamoto T; Horiuchi T; Imanishi H; Odagaki Y; Kawabata K; Sekioka T; Hirota Y; Matsuoka S; Nakai H; Toda M; Cheronis JC; Spruce LW; Gyorkos A; Wieczorek M;
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正文语种 eng
中图分类药学;
关键词
Enzyme Inhibitors; Leukocyte Elastase; Oxadiazoles; Pyrimidinones; ONO-6818; 酶抑制剂; 白细胞弹性蛋白酶; 恶二唑类; 嘧啶酮类;

机译：Enzyme Inhibitors;Leukocyte Elastase;Oxadiazoles;Pyrimidinones;ONO-6818;酶抑制剂;白细胞弹性蛋白酶;恶二唑类;嘧啶酮类;

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专利

1. Design and synthesis of new orally active nonpeptidic inhibitors of human neutrophil elastase. [J] . Ohmoto K, Yamamoto T, Horiuchi T, Journal of Medicinal Chemistry . 2000,第26期

机译：设计和合成新型的人类嗜中性粒细胞弹性蛋白酶的口服非肽类抑制剂。
2. Design and synthesis of new orally active inhibitors of human neutrophil elastase. [J] . Ohmoto K, Okuma M, Yamamoto T, Bioorganic and medicinal chemistry . 2001,第5期

机译：人嗜中性粒细胞弹性蛋白酶的新型口服活性抑制剂的设计与合成。
3. Inhibition of human neutrophil elastase. 4. Design, synthesis, X-ray crystallographic analysis, and structure-activity relationships for a series of P2-modified, orally active peptidyl pentafluoroethyl ketones. [J] . Cregge RJ, Durham SL, Farr RA, Journal of Medicinal Chemistry . 1998,第14期

机译：抑制人类嗜中性粒细胞弹性蛋白酶。 4.一系列P2修饰的口服活性肽基五氟乙基酮的设计，合成，X射线晶体学分析和结构活性关系。
4. Design and synthesis of optically active potential inhibitors of the uptake of neuromediators(DA,NE,5-HT)and y secretase [C] . Maria G.Georgieva, Lyubomir T.Vezenkov, Tchavdar B.Ivanov International Peptide Symposium;European Peptide Symposium . 2005

机译：设计和合成神经对细胞（DA，NE，5-HT）和Y分泌酶摄取的光学活性潜在抑制剂
5. Part One. Synthesis of optically active tryptophan derivatives with potential activity as indoleamine 2,3-dioxygenase inhibitors: An approach via asymmetric catalytic hydrogenation. Part Two. Design, synthesis and pharmacology of selective ligands for alpha1-containing GABA(A)/benzodiazepine receptor subtypes: SAR studies of beta-carbolines at positions -3 and -6 and their corresponding bivalent ligands. Part Three. First enantiospecific total synthesis of the important biogenetic intermediates, (+)-polyneuridine and (+)-polyneuridine aldehyde, as well as 16-epi-vellosimine and macusine A. [D] . Yin, Wenyuan. 2007

机译：第一部分。具有吲哚胺2,3-二加氧酶抑制剂潜在活性的旋光色氨酸衍生物的合成：一种通过不对称催化氢化的方法。第二部分。含α1的GABA（A）/苯并二氮杂receptor受体亚型的选择性配体的设计，合成和药理作用：位于-3和-6位的β-咔啉及其相应的二价配体的SAR研究。第三部分。重要生物遗传中间体，（+）-聚神经氨酸和（+）-聚神经氨酸醛，以及16-表-维西辛和Macusine A的首次对映体全合成。
6. Chemical biochemical pharmacokinetic and biological properties of L-680833: a potent orally active monocyclic beta-lactam inhibitor of human polymorphonuclear leukocyte elastase. [O] . J B Doherty, S K Shah, P E Finke, 1993

机译：L-680833的化学生物化学药代动力学和生物学特性：一种有效的口服的人多形核白细胞弹性蛋白酶的单环β-内酰胺抑制剂。
7. Chemical, biochemical, pharmacokinetic, and biological properties of L-680,833: a potent, orally active monocyclic beta-lactam inhibitor of human polymorphonuclear leukocyte elastase. [O] . Doherty, J B, Shah, S K, Finke, P E, 1993

机译：L-680,833的化学，生化，药代动力学和生物学特性：一种有效的，口服的人多形核白细胞弹性蛋白酶的单环β-内酰胺抑制剂。
8. Design and Synthesis of Orally Active Inhibitors of Botulinum ToxinMetalloproteases [R] . Zdanovsky, A. G. 1997

机译：肉毒毒素蛋白酶口服活性抑制剂的设计与合成

Design and synthesis of new orally active nonpeptidic inhibitors of human neutrophil elastase.

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