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AROMATIC ESTERS OF PHENYLENEDIALKANOATES AS INHIBITORS OF HUMAN NEUTROPHIL ELASTASE.
AROMATIC ESTERS OF PHENYLENEDIALKANOATES AS INHIBITORS OF HUMAN NEUTROPHIL ELASTASE.
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机译:作为人类中性弹性蛋白酶抑制剂的苯二酸氨基酯的芳香族酯。
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摘要
Compounds of the formula IMAGE (I) IMAGE (II) or IMAGE (III) wherein: R1, R2, R3 and R4, which may be the same or different, are selected from the group consisting of hydrogen, alkyl of 1-6 carbons, cycloalkyl of 3 to 6 carbons, alkenyl of 2-6 carbons, or together represent methylene groups -(CH2)n-where n is a whole number from 1 to 6, provided that R1 and R2 or R3 and R4 are not both hydrogen; R5 and R6, which may be the same or different, are selected from the group consisting of hydrogen, halogen, nitro or -S(O)nR7 where n is 0, 1 or 2 and R7 is an optionally substituted alkyl of 1-12 carbons atoms; and both Ar substituents are optionally substituted heteroaromatic rings or one Ar is such heteroaromatic ring and the other is optionally substituted phenyl, the optional substitution for Ar being halogen, nitro or -S(O)nR7 where n and R7 have the value given above. The compounds are useful as inhibitors of human neutrophil elastase.
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机译:式(I)(II)或(III)的化合物,其中:R1,R2,R3和R4可以相同或不同,选自氢,碳原子数为1-6的烷基,碳原子数为3至6的环烷基,碳原子数为2-6的烯基或一起代表亚甲基-(CH2)n-,其中n为1至6的整数,条件是R1和R2或R3和R4都不都是氢; R 5和R 6可以相同或不同,选自氢,卤素,硝基或-S(O)n R 7,其中n为0、1或2,并且R 7为1-12的任选取代的烷基碳原子;并且两个Ar取代基均为任选取代的杂芳族环,或一个Ar为该杂芳族环,另一个为任选取代的苯基,Ar的任选取代基为卤素,硝基或-S(O)nR7,其中n和R7具有以上给出的值。该化合物可用作人嗜中性粒细胞弹性蛋白酶的抑制剂。
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