非肽类蛋白酶抑制剂甲磺酸卡莫司他的合成

摘要

Camostat mesilate was synthesyzed from p-guanidinobenzoic acid hydrochloride and N,N-dimethylcarbamoylmethyl-p-hydroxyphenylacetate using pyridine as catalysts. The total yield was 57.1% with high purity. The process is industrially applicable.%合成甲磺酸卡莫司他。将对胍基苯甲酸盐酸盐制备为酰氯，与对羟基苯乙酸-N， N-二甲基甲酰氨基甲酰甲酯在催化剂吡啶作用下制备甲磺酸卡莫司他，总收率为57.1%。获得高纯度的甲磺酸卡莫司他，本工艺适合工业化生产。