Hydrogen Profiles of Dobutamine Hydrochloride and Fentanyl Citrate Solutions According to Intravenous Administration Systems, Temperature, and Luminosity Conditions

摘要

Factors such as temperature, light exposure, drug concentration, ionic strength, time of infusion, and duration of drug association can influence the effectiveness of pharmacological solutions, which can compromise the solutions' quality, resulting in unstable solutions and drug incompatibility. The aim of this study was to determine the pH of solutions of dobutamine hydrochloride, fentanyl citrate, and their combination in 5% dextrose in water (D5W) under various light exposures and temperature conditions over time.