Improvement of 7 alpha-methoxycephalosporins production by overexpression of cmcJ and cmcI controlled by promoter ermEp* in Streptomyces clavuligerus

Shao L.; Huang J. J.; Yu Y.; Li M. X.; Pu T.; Kan S. D.; Chen D. J.

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Improvement of 7 alpha-methoxycephalosporins production by overexpression of cmcJ and cmcI controlled by promoter ermEp* in Streptomyces clavuligerus

机译：通过启动子ermEp *控制的棒状链霉菌中cmcJ和cmcI的过表达，改善7种α-甲氧基头孢菌素的产生

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摘要

AimThis study aimed to improve the efficiency of bioconversion of cephalosporin C to 7-methoxycephalosporin C.

机译：目的这项研究旨在提高头孢菌素C到7-甲氧基头孢菌素C的生物转化效率。

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来源
《Journal of applied microbiology》 |2014年第6期|共10页
作者
Shao L.; Huang J. J.; Yu Y.; Li M. X.; Pu T.; Kan S. D.; Chen D. J.;
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正文语种 eng
中图分类应用微生物学;
关键词
bioconversion; cephalosporin; genetic engineering; hydroxylation; methylation; Streptomyces clavuligerus; -lactam antibiotics;

机译：生物转化;头孢菌素;基因工程;羟基化;甲基化;棒状链霉菌;-内酰胺类抗生素;

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专利

1. Improvement of 7 alpha-methoxycephalosporins production by overexpression of cmcJ and cmcI controlled by promoter ermEp* in Streptomyces clavuligerus [J] . Shao L., Huang J. J., Yu Y., Journal of applied microbiology . 2014,第6期

机译：通过启动子ermEp *控制的棒状链霉菌中cmcJ和cmcI的过表达，改善7种α-甲氧基头孢菌素的产生
2. Improvement of spinosad production by overexpression of gtt and gdh controlled by promoter PermE* in Saccharopolyspora spinosa SIPI-A2090 [J] . Pan Hai-Xue, Li Ji-An, He Ning-Jun, Biotechnology Letters . 2011,第4期

机译：通过在启动子多孢菌SIPI-A2090中由启动子PermE *控制的gtt和gdh的过量表达来改善多杀菌素的生产
3. Improvement of spinosad production by overexpression of gtt and gdh controlled by promoter PermE* in Saccharopolyspora spinosa SIPI-A2090 [J] . Hai-Xue Pan, Ji-An Li, Ning-Jun He, Biotechnology Letters . 2011,第4期

机译：通过在启动子多孢菌SIPI-A2090中由启动子PermE *控制的gtt和gdh的过量表达来改善多杀菌素的生产
4. Using Structural and Color Features of Streptomyces Clavuligerus Bacteria in Approximating of Production Level of Clavulanic Acid [C] . Nooshin Jafari Fesharaki, Hossein Pourghassem, Maryam Nurmohamadi International conference on computer and network engineering . 2011

机译：利用链霉菌棒状杆菌的结构和颜色特征估算棒酸的生产水平
5. CcaR Is an Autoregulatory Protein That Binds to the ccaR and cefD-cmcI Promoters of the Cephamycin C-Clavulanic Acid Cluster in Streptomyces clavuligerus [O] . Irene Santamarta, Antonio Rodríguez-García, Rosario Pérez-Redondo, 2002

机译：CcaR是与链霉菌克拉维链霉菌中头霉素C-克拉维酸簇的ccaR和cefD-cmcI启动子结合的自调节蛋白
6. CcaR Is an Autoregulatory Protein That Binds to the ccaR and cefD-cmcI Promoters of the Cephamycin C-Clavulanic Acid Cluster in Streptomyces clavuligerus [O] . Santamarta, Irene, Rodríguez-García, Antonio, Pérez-Redondo, Rosario, 2002

机译：CcaR是与链霉菌克拉维链霉菌中头霉素C-克拉维酸簇的ccaR和cefD-cmcI启动子结合的自调节蛋白
7. Bioprocess Modeling and Optimization. Fed-Batch Clavulanic Acid Production by Streptomyces Clavuligerus. [R] . Roubos, J. A. 2002

机译：生物过程建模和优化。链霉菌（streptomyces Clavuligerus）生产补料分批克拉维酸。

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Improvement of 7 alpha-methoxycephalosporins production by overexpression of cmcJ and cmcI controlled by promoter ermEp* in Streptomyces clavuligerus

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