The antibiofilm effects of Byotrol (TM) G32

摘要

Aim The purpose of this study was to evaluate a commercial antimicrobial formulation, Byotrol G32, as a potential coating for impeding biofilm formation on medical devices such as urinary catheters. Methods and Results The antimicrobial activity of Byotrol G32 and its individual constituents has been tested on planktonic and biofilm cultures of uropathogenic bacteria. The Byotrol G32 formulation was superior with MICs ranging from 3gml1 to 15gml1 for planktonic cultures and 320 gml1 for biofilms. Furthermore, Byotrol G32 was able to remove established biofilms and act as an antibiofilm surface coating. Conclusions Byotrol G32 displays impressive antimicrobial activity both in suspension and as a coating. Pretreating medical devices with Byotrol G32 may significantly impede biofilm formation and prolong the lifetime of the device. Significance and Impact of the study Medical devices are indispensable in health care. They are, however, a predisposing factor in infection. This research has demonstrated that Byotrol G32 reduces bacterial growth and subsequent biofilm formation. Application of Byotrol G32 as a medical device coating could have a significant impact on the costs associated with device replacement and patient morbidity and mortality.