DISPERSINB TM, 5-FLUOROURACIL, DEOXYRIBONUCLEASE I AND PROTEINASE K-BASED ANTIBIOFILM COMPOSITIONS AND USES THEREOF

摘要

The present invention provides antibiofilm composition comprising two or moreagents selected from the groupconsisting of DispersinB.TM., 5-Fluorouracil, Deoxyribonuclease I andProteinase K for preventing growth and proliferation ofbiofilm-embedded microorganisms in wound care, oral care, and disease-relatedinfections and methods of treatment in mammals.The invention further provides methods for preparing medical devices, andwound care devices using an antibiofilm compositioncomprising two or more antimicrobial agents selected from the group consistingof DispersinB.TM., 5-Fluorouracil,Deoxyribonucle-ase I and Proteinase K.