Cerebral hamartomas are rare tumor-like lesions composed of disorganized but mature cells, mostly a combination of neuronal or ganglion cells [1]. These lesions are commonly located in the cortex of temporal and frontal lobes, where may determine chronic or medically intractable epilepsy [2]. Hypothalamic hamartomas represent a rare but important model of subcortical epilepsy. Recent clinical studies, primarily based on intracranial seizure recordings, have established that the hypothalamic hamartoma is intrinsically epileptogenic. In some patients, however, the hamartoma contributes to secondary epileptogenesis affecting the neocortex [3]. Hamartomas of the floor of fourth ventricle (HFFV) are extremely rare. To date, only five cases have been reported in literature [4-7].
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