表现为大量蛋白尿的薄基底膜肾病病例报告并文献复习

摘要

目的 探讨以大量蛋白尿为主要临床表现的薄基底膜肾病的诊断、治疗及预后.以期提高对该病的认识和重视,早期获得正确、合理的治疗.方法 回顾性分析我院1例以大量蛋白尿、血尿为主要临床表现的患者的临床资料,经口服黄葵胶囊、双嘧达莫片、复方肾炎片等治疗数月无效,入院后经肾穿刺病理活检,病理诊断为薄基底膜肾病,总结临床资料并对相关文献进行复习.结果 给予对症及糖皮质激素治疗1年,蛋白尿、血尿均转阴.结论 薄基底膜肾病临床上除多数表现为血尿外,也可表现为大量蛋白尿甚至肾病综合征,且对激素治疗敏感.%Objective To explore diagnosis,treatment and prognosis of thin basement membrane nephropathy with heavy proteinuria so as to improve the understanding of the disease,and get the correct and reasonable treatment early.Methods The clinical data of one case were analyzed retrospectively,in which the heavy proteinuria and hematuria were the patient''s manifestation.Heoral Huang Kwai capsule,dipyridamole tablets,compound kidney inflammation tablets were orally administered for several months,but the treatment is invalid.The kidney puncture biopsy pathological examination revealed the diagnosis of thin basement membrane nephropathy.According to the above clinical data we summarized literatures.Results Glucocorticoid treatment was given for one year,and proteinuria and hematuria were negative.Conclusions Althou ghematuria was its predominant finding,TBMN also manifested heavy proteinuria,even nephrotic syndrome,and had good response to hormone therapy.