首页> 外文期刊>Diabetes care >Lifestyle Interaction With Fat Mass and Obesity-Associated (FTO) Genotype and Risk of Obesity in Apparently Healthy U.S. Women.
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Lifestyle Interaction With Fat Mass and Obesity-Associated (FTO) Genotype and Risk of Obesity in Apparently Healthy U.S. Women.

机译:生活方式健康的美国妇女中与脂肪量和肥胖相关(FTO)基因型的生活方式相互作用以及肥胖风险。

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摘要

OBJECTIVE Variation in the fat mass and obesity-associated (FTO) gene is associated with obesity. The extent to which separate and combined effects of physical activity and caloric intake modify this association remains unclear. RESEARCH DESIGN AND METHODS FTO polymorphism rs8050136 was measured, and physical activity, caloric intake, and anthropometrics were self-reported in 21,675 apparently healthy Caucasian women. RESULTS The effect of the risk allele (A) on BMI was larger among inactive or higher intake women, with additive effects of inactivity and high intake on the associated genetic risk. Specifically, each A allele was associated with mean BMI difference of +0.73 (SE 0.08) kg/m(2) among inactive women (8.8 MET-hours/week). Similarly, each A allele was associated with mean BMI difference of +0.65 (0.07) among high intake women (>median, 1,679 kcals/day), compared with +0.38 (0.07) kg/m(2), P = 0.005, among low intake women (
机译:目的脂肪量和肥胖相关(FTO)基因的变异与肥胖有关。体育活动和热量摄入的单独和联合作用在多大程度上改变了这种联系,目前尚不清楚。研究设计和方法测量了FTO多态性rs8050136,并自我报告了21675名显然健康的白种女性的身体活动,热量摄入和人体测量学。结果风险等位基因(A)对不活跃或摄入量较高的女性的BMI影响更大,不活跃和摄入量高对相关遗传风险的累加效应。具体而言,每个A等位基因与非活动女性之间的平均BMI差异为+0.73(SE 0.08)kg / m(2)(中位数为8.8 MET小时/周),而+0.31(0.06)kg / m在活跃妇女中(> 8.8 MET小时/周),m(2),P <0.0001。同样,每个等位基因与高摄入量女性(>中位数,1,679 kcal /天)之间的平均BMI差异为+0.65(0.07),而+0.38(0.07)kg / m(2),P = 0.005,低摄入量妇女(

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