首页> 外文期刊>Basic & clinical pharmacology & toxicology. >Antioxidant therapy reduces oxidative and inflammatory tissue damage in patients subjected to cardiac surgery with extracorporeal circulation.
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Antioxidant therapy reduces oxidative and inflammatory tissue damage in patients subjected to cardiac surgery with extracorporeal circulation.

机译:抗氧化剂治疗减少了体外循环心脏手术患者的氧化和炎性组织损伤。

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摘要

Ischaemia reperfusion injury is a pathophysiological event that occurs after cardiac surgery with extracorporeal circulation. This clinical event has been associated with the induction of oxidative and inflammatory damage in atrial tissue. Here, we tested whether combined omega 3 polyunsaturated fatty acids (n-3 PUFA)-antioxidant vitamin protocol therapy reduces oxidative and inflammatory cardiac tissue damage. This trial assigned 95 either-sex patients to supplementation with n-3 PUFA (2 g/day), or matching placebo groups, 7 days before on-pump surgery. Antioxidant vitamins C (1 g/day) and E (400 IU/day) or placebo were added from 2 days before surgery until discharge. Blood and atrial tissue samples were obtained during the intervention. Reduced/oxidized glutathione (GSH/GSSG) ratio, malondialdehyde (MDA) and protein carbonylation were determined in atrial tissue. Leucocyte count and high-sensitivity C-reactive protein (hs-CRP) in blood plus nuclear factor (NF)-kappaappaB activation in atrial tissue served for inflammation assessment. Lipid peroxidation and protein carbonylation were 27.5 and 24% lower in supplemented patients (p < 0.01). GSH/GSSG ratio was 38.1% higher in supplemented patients compared with placebo (p < 0.01). Leucocyte count and serum hs-CRP levels were markedly lower throughout the protocol in supplemented patients (p < 0.01). Atrial tissue NF-kappaB DNA activation in supplemented patients was 22.5% lower than that in placebo patients (p < 0.05). The combined n-3 PUFA-antioxidant vitamin protocol therapy here proposed reduced the oxidative stress and inflammation biomarkers, in patients undergoing on-pump cardiac surgery.
机译:缺血再灌注损伤是在心脏手术后体外循环后发生的病理生理事件。该临床事件与心房组织中氧化性和炎性损伤的诱导有关。在这里,我们测试了欧米茄3多不饱和脂肪酸(n-3 PUFA)-抗氧化剂维生素协议疗法的联合治疗是否能减少氧化性和炎症性心脏组织损伤。该试验在泵吸手术前7天为95名非性别患者补充n-3 PUFA(2 g /天)或安慰剂组。从手术前两天直至出院,添加抗氧化剂维生素C(1 g /天)和E(400 IU /天)或安慰剂。干预期间获得了血液和心房组织样本。测定了心房组织中还原型/氧化型谷胱甘肽(GSH / GSSG)的比例,丙二醛(MDA)和蛋白羰基化。血液中白细胞计数和血液中的高敏C反应蛋白(hs-CRP)加上心房组织中核因子(NF)-κB的活化可用于炎症评估。补充患者的脂质过氧化和蛋白质羰基化分别降低27.5和24%(p <0.01)。与安慰剂相比,接受补充治疗的患者的GSH / GSSG比率高38.1%(p <0.01)。在整个方案中,补充患者的白细胞计数和血清hs-CRP水平明显降低(p <0.01)。补充患者的心房组织NF-κBDNA活化比安慰剂患者低22.5%(p <0.05)。本文提出的联合n-3 PUFA-抗氧化剂维生素方案治疗可降低接受心脏泵手术的患者的氧化应激和炎症生物标志物。

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