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首页> 外文期刊>Human and Experimental Toxicology >Supplementation of ascorbic acid prevents oxidative damages in arsenic-loaded hepatic tissue of rat: an ex vivo study.
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Supplementation of ascorbic acid prevents oxidative damages in arsenic-loaded hepatic tissue of rat: an ex vivo study.

机译:补充抗坏血酸可防止砷对大鼠肝组织的氧化损伤:一项离体研究。

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摘要

Oxidative stress due to arsenic toxicity and ameliorative potentiality of L-ascorbic acid was evaluated in an ex vivo system of rat hepatic tissue. The study revealed that arsenic increased the activity of superoxide dismutase (SOD) and catalase (CAT) and the level of lipid peroxidation (LPO), protein carbonyl (PC) and nitric oxide (NO) at 1 hour, 1.5 hours and 2 hours of incubation. Co-treatment with L-ascorbic acid was found effective to normalize the activity of SOD and CAT and the production of LPO, PC and NO in hepatic tissue. This ex vivo study suggested that ascorbic acid is helpful to ameliorate arsenic-induced oxidative stress. This may be one of the alternative screening systems to study the efficacy of antioxidant and hepatoprotective agent.
机译:在大鼠肝组织的离体系统中,评估了由于砷毒性和L-抗坏血酸的改善潜力而产生的氧化应激。研究表明,在1、2、5和2小时,砷增加了超氧化物歧化酶(SOD)和过氧化氢酶(CAT)的活性以及脂质过氧化(LPO),蛋白羰基(PC)和一氧化氮(NO)的水平。孵化。发现与L-抗坏血酸的共处理可有效地标准化肝组织中SOD和CAT的活性以及LPO,PC和NO的产生。这项离体研究表明抗坏血酸有助于缓解砷诱导的氧化应激。这可能是研究抗氧化剂和肝保护剂功效的替代筛选系统之一。

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