Methods for closing and opening a semichannel and a cell, organic tissue or organ, to prevent or treat the stress of organic tissue or organ in a mammal, to increase intracellular communication of the gap junction in a cell, organic tissue or organ. for the treatment of burns, thrombosis, respiratory and metabolic acidosis, and focal arrhythmia, for the treatment and prevention of cell and organ tissue damage resulting from elevated blood glucose levels, for the treatment of chronic atrial fibrillation and epilepsy, to create compound candidates that modulate semi-channel function, to cytoprotect organic tissue or an organ of a mammal in need of such treatment, and to prevent or treat reperfusion damage in a mammal

摘要

"METHODS FOR CLOSING AND OPENING A SEMI-CHANNEL IN A CELL, ORGANIC TISSUE OR ORGAN, TO PREVENT OR TREATING ORGANIC TISSUE STRESS, TO INCREASE COMMUNICATION OF THE INTRACULAR OR CELLULAR INTRACULAR COMMUNICATION ORGAN, FOR TREATMENT OF BURNS, THROMBOSIS, RESPIRATORY AND METABOLIC ACIDOSIS, AND FOCUS ARRYTHMIA, TO TREAT AND PREVENT CELL DAMAGE AND ORGANIC TISSUE RESULTING FROM HIGH GLUOSE CROSPLE ETALY TREPTIZE NPS levels , TO CREATE CANDIDATE COMPOUNDS THAT MODULE THE SEMI-CHANNEL FUNCTION, TO CYTO PROTECT ORGANIC FABRIC OR AN ORGAN OF A MAMMER IN NEED FOR SUCH TREATMENT, AND TO PREVENT OR TREAT REPERFUSION DAMAGE ". Compositions and methods for modulating semi-channel function in a cell, organic tissue or organ are disclosed. The invention also relates to screenings useful for detecting such compounds, particularly those capable of modulating connexin phosphorylation. Therapeutic methods are also provided to prevent or treat conditions impacted by unwanted semi-channel function in a mammal such as cardiac arrhythmia.