Asymmetric ring opening of terminal epoxides via kinetic resolution catalyzed by new bimetallic chiral (salen)Co complexes

摘要

The highly enantioselective hydrolytic kinetic resolution (HKR) of racemic terminal epoxides by new bimetallic chiral (salen)Co provides a operationally very simple protocol for the synthesis of enantiomerically enriched terminal epoxides (> 99% ee) and diols. Optically pure chlorohydrins have been synthesized in one step by ring-opening reactions of terminal epoxides with HCl using kinetic resolution. (c) 2005 Wiley-Liss, Inc.