The effect of long-term supplemental dietary cadmium on lipid peroxidation and the antioxidant system in the liver and kidneys of rabbits

摘要

We investigated the effects of chronic exposure to dietary cadmium (Cd) on lipid peroxidation (LPO) and reduced glutathione (GSH) associated with activities of glutathione peroxidase (GSH-Px) and the catalase (CAT) enzyme in the liver and kidneys ofrabbits. Twenty 10-month-old clinically healthy New Zealand white rabbits (10/group) with an average body weight of 3545+-250 g were used. The control group was allowed to take food and tap water ad libitum, while the experimental group was given tap water containing 200 ppm CdCl2/litre for 28 weeks. Lipid peroxidation contents increased significantly in the liver (P < 0.001) and kidneys (P < 0.005) of Cd-treated rabbits. Glutathione levels decreased significantly in both the liver (P < 0.001) and the kidneys (P < 0.005) of the experimental group. Cd caused a significant decrease in the activities of GSH-Px and CAT in the liver (P < 0.001, P < 0.01) and kidneys (P < 0.005, P < 0.1) of the rabbits. These results indicated that Cd-induced an increase inLPO and was associated with reductions in GSH-Px and CAT enzyme activities in GSH levels in the liver and kidneys of rabbits.