EGFR expression and the flexibility of FLEX.

摘要

In The Lancet Oncology, Robert Pirker and colleagues report on further analysis of the FLEX-study where they calculate an immunohistochemistry score (H score) to provide a more detailed assessment of EGFR protein expression and how this affects response to treatment with cetuximab in patients with advanced non-small-cell lung cancer (NSCLC).The H score takes into account the percentage of cells (0-100%) in each intensity category (0-3+) and computes a final score, on a continuous scale between 0 and 300. Here, a cutoff value of 200 was used to define high and low EGFR expressing groups.