Secretion of prostaglandins E2 and F2alpha by the bovine endometrium in response to oxytocin during the estrous cycle.

摘要

Endometrium was obtained at different stages of the oestrous cycle of cows. After 1 h of preincubation, endometrium was exposed to 0 or 100 nM oxytocin for 4 h. The concentration of PGE2 in the medium was higher than that of PGF2alpha during the luteal phase of the oestrous cycle, and declined at the regressed luteal stage (P<0.05). The secretion of PGF2alpha was highest at the regressed luteal stage (P<0.05). Oxytocin significantly stimulated the secretion of both PGs at the early luteal stage (P<0.05). Although oxytocin enhanced PGF2alpha secretion at the late and regressed luteal stages (P<0.05), PGE2 secretion was reduced by oxytocin at these times (P<0.05).