Remarkable Selectivity in Derivatization and Protection of Hydroxy Groups of 51-hydroxyCTX3C: Chemoselective Synthesis of Biotin-conjugated Ciguatoxin Derivatives

摘要

Ciguatoxins, principal causative toxins of ciguatera seafood poisoning, are large ladder-like polycyclic ethers that exert their toxicities by binding to the voltage-sensitive sodium channels. We report C7/C51 chemoselective derivatization of 51-hy-droxyCTX3C applicable for synthesis of biological probes.