3S, 4S-TRANS-2, 2-DIALKYL-3- SUBSTITUTED PHENYL-4-(HYDROXY-SUBSTITUTED PHENYL)-SUBSTITUTED CHROMAN DERIVATIVES AS USEFUL INTERMEDIATES FOR THE SYNTHESIS OF SELECTIVE ESTROGEN MODULATORS

摘要

'This invention relates to (+)- 3S, 4S -trans - 2,2-dialkyl -3- substituted phenyl-4-(hydroxy substituted phenyl)- substituted chromans, process for their preparation, as key intermediates for the preparation of tissue selective estrogens as Pharmaceuticals,