Expression of bone morphogenetic proteins,matrix metalloproteinases and inhibitors of matrix metalloproteinases in lung cancers and their prognostic significance

摘要

Matrix metalloproteinases (MMP) and their tissue inhibitors (TIMP) are one of the molecules that have become a topic of great interest among scientists studying lung cancers.There is a distinct tendency toward higher expression of selected MMP and TIMP in tumor lung tissue.Furthermore,there is a significant correlation between high expression of TIMP-1 or MMP-2 in lung cancer and shortened survival and between high expression of TIMP-1 or MMP-7 in lung cancer and higher stage of disease.There have been only a few articles about the role of bone morphogenetic proteins (BMP) in lung cancer pathogenesis published so far in which BMP-2 or BMP-4 were overexpressed.It was also shown that BMP-2 stimulates tumor growth while BMP-4 inhibits it.This article is mainly concentrated on the expression of MMP,TIMP and BMP in lung cancers,but also it shows the significance of these proteins.