Synthesis of heterobifunctional poly(ethylene glycol) with a primary amino group at one end and a carboxylate group at the other end

摘要

A novel synthetic route to heterobifunctional poly(ethylene glycol) containing both amino and carboxylate terminal groups was established via anionic polymerization of ethylene oxide using (cyanomethyl)potassium as the initiator, followed by the successive conversion of the end-hydroxyl group to a primary amino group, and hydrolysis of the cyano group to a carboxylate group.