Synthesis and LC-MS/MS analysis of desmosine-CH_2, a potential internal standard for the degraded elastin biomarker desmosine

摘要

Desmosine-CH_2, an analog of the elastic tissue degradation biomarker desmosine, can be regarded as a potential internal standard for precise quantification of desmosines by LC-MS/MS. In this study, the chemical synthesis of desmosine-CH_2 was completed in 22% overall yield in five steps. The LC-MS/MS analysis of desmosine-CH_2 was also achieved.