Effects of pigment extract from black glutinous corncob in a high-fat-fed mouse model of hyperlipidemia

摘要

This study was designed to evaluate the effect of pigments extracted from black glutinous corncob (BGC) on hyperlipidemia in high-fat-fed mice. Our previous studies showed that pigment from BGC (PBGC) is an anthocyanin and can markedly reduce oxidative stress and scavenge free radicals. PBGC was isolated and prepared by extraction in 1% hydrochloric acid ethyl alcohol solution. Mice were divided into five groups of ten mice each: group I were healthy controls, group II were fed a cholesterol-rich diet only, while groups III to V were fed a cholesterol-rich diet and were fed PBGC by gavage at 200, 500, and 800 mg/kg body weight, respectively, for 4 weeks. The results indicated that PBGC significantly lowered the plasma total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglyceride (TG) and markedly increased the serum high-density lipoprotein cholesterol (HDL-C), compared with the hyperlipidemia control group (P < 0.01). Moreover, administration of PBGC significantly decreased the atherogenic index (AI). The present results suggest that PBGC has great potential for preventing hyperlipidemia and cerebrovascular diseases.