Anti-hyperlipidemia Effects of a Water extract of Artemisiaiwayomogi Kitamura and Curcuma longa Linne. (ACE) in mouse model induced poloxamer 407

摘要

Purpose: To investigate anti-hyperlipidemic effects ofACE against poloxamer 407(P-407)-induced hyperlipidemia ofC57/BL 6 mice model. Serum and hepatic tissue lipid profiles,hyperlipidemia related - gene expressions and protein levelsof the hepatic tissue were measured.Methods: C57BL/6 micewere orally administrated with distilledwater, Artemisia iwayomogi Kitamura(AR)50 mg/kg orCurcuma longa Linne(CU) 50 mg/kg, ACE(25 or 50 or 100 mg/kg)or Lipitor(50 mg/kg) for 13 weeks (n=10 or 11 per group). Micewere injected P-407(500 mg/kg) two times in everyweeks. After13 weeks, we measured serum lipid parameters such as totalcholesterol (TC), triglycerides (TG), and hyperlipidemic geneand protein expressionswere evaluated in the heaptic tissues.