Pharmacokinetics of Coadministration of Guanfacine Extended Release and Methylphenidate Extended Release

Benno Roesch; Mary Corcoran; Mary Haffey; Annette Stevenson; Phillip Wang; Jaideep Purkayastha; Patrick Martin; James Ermer

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Pharmacokinetics of Coadministration of Guanfacine Extended Release and Methylphenidate Extended Release

机译：胍法辛缓释和哌醋甲酯缓释共同给药的药代动力学

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Background α2-Adrenoceptor agonists are used adjunctively to psychostimulants in treating attention-deficit/hyperactivity disorder (ADHD) when psychostimulants alone do not sufficiently reduce symptoms. However, data on the pharmacokinetic profiles and safety of combination treatments in ADHD are needed.

机译：背景技术α2-肾上腺素能受体激动剂可在精神兴奋剂不能单独减轻症状的情况下辅助使用于精神兴奋剂治疗注意力不足/多动症（ADHD）。但是，需要有关ADHD中药代动力学特征和联合治疗安全性的数据。

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《Drugs in R&D》 |2013年第1期|53-61|共9页
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Benno Roesch; Mary Corcoran; Mary Haffey; Annette Stevenson; Phillip Wang; Jaideep Purkayastha; Patrick Martin; James Ermer;
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1. Pharmacokinetics of Coadministration of Guanfacine Extended Release and Methylphenidate Extended Release [J] . Benno Roesch, Mary Corcoran, Mary Haffey, Drugs in R&D . 2013,第1期

机译：胍法辛缓释和哌醋甲酯缓释共同给药的药代动力学
2. A Comparison of the Pharmacokinetics of Methylphenidate Extended‐Release Orally Disintegrating Tablets With a Reference Extended‐Release Formulation of Methylphenidate in Healthy Adults [J] . Childress Ann, Stark Jeffrey G., McMahen Russ, Clinical pharmacology in drug development . 2018,第2期

机译：甲基酚盐延伸口腔崩解片剂的药代动力学对健康成人甲基酚的参考延长释放片剂进行比较
3. Pharmacokinetics of HLD200, a Delayed-Release and Extended-Release Methylphenidate: Evaluation of Dose Proportionality, Food Effect, Multiple-Dose Modeling, and Comparative Bioavailability with Immediate-Release Methylphenidate in Healthy Adults [J] . Liu Tao, Gobburu Jogarao V. S., Po Michelle D., Journal of child and adolescent psychopharmacology . 2019,第3期

机译：HLD200的药代动力学，延迟释放和延长释放甲基苯胺：对剂量比例，食物效应，多剂量建模和对健康成年人的即时释放甲基酚的比较生物利用度评估
4. Dose Proportional Pharmacokinetics of a Methylphenidate Extended-Release Capsule Formulation [C] . Controlled Release Society annual meeting . 2004

机译：甲基酚盐延长释放胶囊配方的剂量比例药代动力学
5. Development of an extended release naproxen sodium matrix tablet and evaluation of the effects of various fillers and additives on drug release kinetics. [D] . Patel, Maulik R. 2011

机译：萘普生钠缓释片的研制以及对各种填充剂和添加剂对药物释放动力学的影响的评估。
6. Pharmacokinetics of Coadministration of Guanfacine Extended Release and Methylphenidate Extended Release [O] . Benno Roesch, Mary Corcoran, Mary Haffey, 2013

机译：胍法辛缓释和哌醋甲酯缓释共同给药的药代动力学
7. Pharmacokinetics of Coadministration of Guanfacine Extended Release and Methylphenidate Extended Release [O] . Benno Roesch, Mary Corcoran, Mary Haffey, 2013

机译：胍法辛缓释和哌醋甲酯缓释共同给药的药代动力学

Pharmacokinetics of Coadministration of Guanfacine Extended Release and Methylphenidate Extended Release

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