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Clinical pharmacology in drug development

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中文名称：临床药理学的药物开发

ISSN：2160-763X
出版周期：Quarterly

发文量：186

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1.Evaluation of the effect of mericitabine at projected therapeutic and supratherapeutic doses on cardiac repolarization in healthy subjects: A thorough QT/QTc study

机译：评价预估的治疗和治疗上剂量的美利他滨对健康受试者心脏复极的影响：全面的QT / QTc研究
- 作者：ChenY.-C.;HaznedarJ.;KulkarniR.;VistuerC.;WashingtonC.;LiuM.;SmithP.
- 期刊名称：《Clinical pharmacology in drug development》 | 2014年第3期
- Clinical trial;
- Electrocardiography;
- Healthy subject;
- Mericitabine;
- Thorough QT/QTc study;
2.Steady-state pharmacokinetics of sirolimus in stable adult Chinese renal transplant patients

机译：西罗莫司在稳定的中国成年肾移植患者中的稳态药代动力学
- 作者：WangH.F.;QiuF.;WuX.;FangJ.;CrownoverP.;Korth-BradleyJ.;SchulmanS.
- 期刊名称：《Clinical pharmacology in drug development》 | 2014年第3期
- Chinese;
- Pharmacogenomics;
- Pharmacokinetics;
- Renal transplant;
- Sirolimus;
3.Pharmacokinetics and pharmacodynamics of GSK961081, a novel inhaled muscarinic antagonist β2-agonist, and fluticasone propionate administered alone, concurrently and as a combination blend formulation in healthy volunteers

机译：新型吸入式毒蕈碱拮抗剂β2-激动剂GSK961081和丙酸氟替卡松的药代动力学和药效学，分别，并用和联合掺和，用于健康志愿者
- 作者：NorrisV.;AmberyC.;RileyT.
- 期刊名称：《Clinical pharmacology in drug development》 | 2014年第4期
- Bi-functional molecule;
- Bronchodilator;
- Fluticasone propionate;
- GSK961081;
4.A single and multiple dose study to investigate the pharmacokinetics of a prolonged release formulation of ropinirole in healthy Chinese subjects

机译：单次和多次剂量研究，研究罗匹尼罗缓释制剂在中国健康人群中的药代动力学
- 作者：LiuH.;JiangJ.;WangH.;ChenX.;LiuT.;CaoH.;PalmerJ.;GuA.;HuP.
- 期刊名称：《Clinical pharmacology in drug development》 | 2014年第2期
- Chinese;
- Healthy subjects;
- Pharmacokinetics;
- Ropinirole;
5.Evaluation of the pharmacokinetics and pharmacodynamics of two leuprolide acetate 45mg 6-month depot formulations in patients with prostate cancer

机译：两种醋酸醋酸亮丙瑞林45mg 6个月长效制剂在前列腺癌患者中的药代动力学和药效学评估
- 作者：MostafaN.M.;ChwaliszK.;LarsenL.;Mattia-GoldbergC.;SpitzA.;PradhanR.S.
- 期刊名称：《Clinical pharmacology in drug development》 | 2014年第4期
- GnRH agonist;
- Leuprolide;
- Pharmacodynamics;
- Pharmacokinetics;
6.Safety, tolerability, pharmacokinetics, and pharmacodynamics of fluticasone furoate, a novel inhaled corticosteroid, in children aged 5-11 years with persistent asthma: A randomized trial

机译：氟替卡松糠酸酯（一种新型的吸入性糖皮质激素）在5-11岁持续性哮喘儿童中的安全性，耐受性，药代动力学和药效学：一项随机试验
- 作者：OliverA.;AllenA.;VanburenS.;HamiltonM.;TombsL.;KempsfordR.;QaqundahP.
- 期刊名称：《Clinical pharmacology in drug development》 | 2014年第2期
- Asthma;
- Children;
- Fluticasone furoate;
- Pharmacokinetics and pharmacodynamics;
- Tolerability;
7.Evaluation of potential for pharmacokinetic interaction between mometasone furoate and formoterol fumarate after oral inhalation from a fixed-dose combination metered-dose inhaler device

机译：从固定剂量组合计量吸入器口服吸入后，评估糠酸莫米松和富马酸福莫特罗之间药代动力学相互作用的潜力
- 作者：KosoglouT.;HubbellJ.;Johnson-LevonasA.O.;YunanM.;KantesariaB.S.;CutlerD.L.
- 期刊名称：《Clinical pharmacology in drug development》 | 2014年第3期
- Asthma;
- COPD;
- Formoterol fumarate;
- Inhaler;
- Mometasone furoate;
- Pharmacokinetics;
8.In vitro dissolution and in vivo bioequivalence evaluation of two brands of trimetazidine tablets

机译：两种品牌曲美他嗪片的体外溶出度和体内生物等效性评估
- 作者：HelmyS.A.;MansourN.O.
- 期刊名称：《Clinical pharmacology in drug development》 | 2014年第2期
- Bioequivalence;
- Dissolution;
- HPLC;
- Pharmacokinetics;
- Trimetazidine;
9.Effect of moxidectin on CYP3A4 activity as evaluated by oral midazolam pharmacokinetics in healthy subjects

机译：口服咪达唑仑药代动力学评估莫昔克丁对CYP3A4活性的影响
- 作者：Korth-BradleyJ.M.;ParksV.;WagnerF.;ChalonS.;GourleyI.;MatschkeK.;GossartS.;RippS.L.;FleckensteinL.
- 期刊名称：《Clinical pharmacology in drug development》 | 2014年第2期
- CYP3A4;
- Drug interaction;
- Midazolam;
- Moxidectin;
- Onchocerciasis;
10.Pharmacokinetic bioequivalence crossover study of branded generic and innovator formulations of the cholesterol lowering agent ezetimibe

机译：降胆固醇剂依泽替米贝品牌通用和创新制剂的药代动力学生物等效性交叉研究
- 作者：PalmerJ.L.;KunhihitluA.;CostantiniA.;EsquivelF.;RoushJ.;EdwardsK.;HillT.W.K.
- 期刊名称：《Clinical pharmacology in drug development》 | 2014年第3期
- Bioequivalence;
- Branded generic;
- Ezetimibe;
- Innovator;
11.The effect of maraviroc on the pharmacokinetics of digoxin in healthy volunteers

机译：马拉维罗对健康志愿者地高辛药代动力学的影响
- 作者：VourvahisM.;FangJ.;ChooH.W.;HeeraJ.
- 期刊名称：《Clinical pharmacology in drug development》 | 2014年第3期
- CCR5 antagonist;
- Digoxin;
- Maraviroc;
- P-glycoprotein;
- Pharmacokinetics;
12.Orlistat improves psychomotor performance in humans

机译：奥利司他改善人类的精神运动表现
- 作者：Al-NimerM.S.M.;Al-GareebA.I.;Al-KuraishyH.M.
- 期刊名称：《Clinical pharmacology in drug development》 | 2014年第2期
- Nitrogen species;
- Orlistat;
- Psychomotor performance;
13.Sleep-promoting medications: Weighing the hazards of use versus non-use

机译：促睡眠药物：权衡使用与不使用之间的危害
- 作者：GreenblattD.J.
- 期刊名称：《Clinical pharmacology in drug development》 | 2014年第3期
14.Pharmacokinetics and pharmacodynamics of guanfacine extended release in adolescents aged 13-17 years with attention-deficit/hyperactivity disorder

机译：胍法辛缓释药物在13-17岁青少年中的药动学和药效学
- 作者：MartinP.;SatinL.;VinceB.D.;PadillaA.F.;WhiteC.;CorcoranM.;StevensonA.;ErmerJ.
- 期刊名称：《Clinical pharmacology in drug development》 | 2014年第4期
- Pediatrics;
- Pharmaceutical medicine;
- Pharmacodynamics;
- Pharmacokinetics and drug metabolism;
- Psychopharmacology;
15.The effect of rifampin on the pharmacokinetics of sirolimus in healthy volunteers

机译：利福平对健康志愿者西罗莫司药代动力学的影响
- 作者：TortoriciM.A.;MatschkeK.;Korth-BradleyJ.M.;DileaC.;LasseterK.C.
- 期刊名称：《Clinical pharmacology in drug development》 | 2014年第1期
- Drug interaction;
- Healthy volunteers;
- Rifampin;
- Sirolimus;
16.Caspofungin exposure-response relationships in adult patients with mucosal or invasive candidiasis

机译：成人黏膜或浸润性念珠菌病患者卡泊芬净暴露-反应关系
- 作者：ComisarW.;SunP.;LiS.;SableC.;SchwartzM.;BiS.;ChowJ.;NgaiA.;WinchellG.;KartsonisN.;StoneJ.
- 期刊名称：《Clinical pharmacology in drug development》 | 2014年第1期
- Caspofungin;
- Invasive candidiasis;
- Mucosal candidiasis;
- Pharmacodynamics;
- Pharmacokinetics;
17.No influence of the CYP2C19-selective inhibitor omeprazole on the pharmacokinetics of the dopamine receptor agonist rotigotine

机译：CYP2C19选择性抑制剂奥美拉唑对多巴胺受体激动剂罗替戈汀的药代动力学没有影响
- 作者：ElshoffJ.-P.;CawelloW.;AndreasJ.-O.;BraunM.
- 期刊名称：《Clinical pharmacology in drug development》 | 2014年第3期
- CYP2C19;
- Drug-drug interactions;
- Omeprazole;
- Pharmacokinetics;
- Rotigotine transdermal system;
18.A randomized, double-blind, multiple-dose, placebo-controlled, dose escalation study with a 3-cohort parallel group design to investigate the tolerability and pharmacokinetics of albaconazole in healthy subjects

机译：一项随机，双盲，多剂量，安慰剂对照的剂量递增研究，采用三组平行研究，旨在研究阿尔巴康唑在健康受试者中的耐受性和药代动力学
- 作者：DietzA.J.;BarnardJ.C.;vanRossemK.
- 期刊名称：《Clinical pharmacology in drug development》 | 2014年第1期
- Albaconazole;
- Onychomycosis;
- Pharmacokinetics;
- QTc;
- Supratherapeutic dose;
19.Safety, tolerability, pharmacokinetics, and pharmacodynamics of vilanterol, a novel inhaled long-acting β-agonist, in children aged 5-11 years with persistent asthma: A randomized trial

机译：5-11岁持续性哮喘儿童维兰特罗的安全性，耐受性，药代动力学和药效学：一种新颖的吸入长效β-激动剂：一项随机试验
- 作者：OliverA.;VanburenS.;AllenA.;HamiltonM.;TombsL.;KempsfordR.;QaqundahP.
- 期刊名称：《Clinical pharmacology in drug development》 | 2014年第3期
- Asthma;
- Children;
- Pharmacokinetics and pharmacodynamics;
- Tolerability;
- Vilanterol;
20.Comparison study of plasma coenzyme Q10 levels in healthy subjects supplemented with ubiquinol versus ubiquinone

机译：补充泛醇和泛醌的健康受试者血浆辅酶Q10水平的比较研究
- 作者：LangsjoenP.H.;LangsjoenA.M.
- 期刊名称：《Clinical pharmacology in drug development》 | 2014年第1期
- Coenzyme Q10;
- Plasma level;
- Supplementation;
- Ubiquinol;
- Ubiquinone;
21.Lack of tyramine pressor response effect with oral CX157: A specific reversible MAOI

机译：口服CX157缺乏酪胺升压反应的作用：一种特殊的可逆MAOI
- 作者：BurchD.;AsgharnejadM.;GersonW.;FieldingR.M.;AzzaroA.J.
- 期刊名称：《Clinical pharmacology in drug development》 | 2014年第1期
- CX157;
- Depression;
- Reversible monoamine oxidase inhibitor;
- TriRima;
- Tyramine pressor test;
22.Population pharmacokinetic analysis of dutogliptin, a selective dipeptidyl peptidase-4 inhibitor

机译：选择性二肽基肽酶4抑制剂dutogliptin的群体药代动力学分析
- 作者：MarierJ.-F.;MouksassiM.-S.;GosselinN.H.;LiJ.
- 期刊名称：《Clinical pharmacology in drug development》 | 2014年第4期
- DPP-4 inhibitor;
- Dutogliptin;
- Pharmacokinetics;
- Sources of variability;
23.A phase 1, randomized study to assess the pharmacokinetic comparability of siltuximab derived from two different cell lines in healthy subjects

机译：1期随机研究，评估健康受试者中源自两种不同细胞系的Siltuximab的药代动力学可比性
- 作者：XuC.;HanC.;MariniJ.;FordJ.;MarciniakS.;LopezM.;FrederickB.;deVriesD.;BandekarR.;DavisH.M.;ZhouH.;PuchalskiT.A.
- 期刊名称：《Clinical pharmacology in drug development》 | 2014年第4期
- Bioequivalence;
- Biologics;
- Manufacturing change;
- Pharmacokinetics;
- Siltuximab;
24.Pharmacokinetics and comparative bioavailability of domperidone suspension and tablet formulations in healthy adult subjects

机译：多潘立酮混悬剂和片剂在健康成人受试者体内的药代动力学和比较生物利用度
- 作者：HelmyS.A.;ElBedaiwyH.M.
- 期刊名称：《Clinical pharmacology in drug development》 | 2014年第2期
- Bioavailability;
- Domperidone;
- Fluorescence;
- HPLC;
- Pharmacokinetics;
25.The pharmacokinetics of darexaban (YM150), an oral direct factor Xa inhibitor, are not affected by ketoconazole, a strong inhibitor of CYP3A and P-glycoprotein

机译：口服直接因子Xa抑制剂darexaban（YM150）的药代动力学不受CYP3A和P-糖蛋白的强抑制剂酮康唑的影响
- 作者：GroenendaalD.;StrabachG.;Garcia-HernandezA.;KadokuraT.;HeeringaM.;MolR.;EltinkC.;OnkelsH.
- 期刊名称：《Clinical pharmacology in drug development》 | 2014年第3期
- Anticoagulant;
- CYP3A;
- Darexaban;
- Factor Xa inhibitor;
- Ketoconazole;
- P-glycoprotein;
- Pharmacokinetics;
- YM150;
26.Effect of the thrombin receptor antagonist (PAR-1) vorapaxar on QT/QTc interval in healthy volunteers: A randomized, placebo- and positive-controlled, parallel group trial

机译：凝血酶受体拮抗剂（PAR-1）vorapaxar对健康志愿者的QT / QTc间隔的影响：一项随机，安慰剂和阳性对照的平行组试验
- 作者：KosoglouT.;HuntT.L.;XuanF.;KumarB.;StatkevichP.;HansonM.E.;CutlerD.L.
- 期刊名称：《Clinical pharmacology in drug development》 | 2014年第1期
- Cardiac safety;
- PAR-1;
- QT/QTc prolongation;
- Thrombin receptor antagonist;
- Vorapaxar;
27.Bioavailability of valsartan oral dosage forms

机译：缬沙坦口服剂型的生物利用度
- 作者：SunkaraG.;BendeG.;MendonzaA.E.;Solar-YohayS.;BiswalS.;NeelakanthamS.;WagnerR.;FlarakosJ.;ZhangY.;JarugulaV.
- 期刊名称：《Clinical pharmacology in drug development》 | 2014年第2期
- Pediatric formulations;
- Pharmacokinetics;
- Valsartan;
28.Analgesic and decongestant efficacy of the combination of aspirin with pseudoephedrine in patients with symptoms of upper respiratory tract infection

机译：阿司匹林与伪麻黄碱联用对上呼吸道感染症状的镇痛和去充血功效
- 作者：EcclesR.;VoelkerM.
- 期刊名称：《Clinical pharmacology in drug development》 | 2014年第2期
- Acetylsalicylic acid;
- Acute pain;
- Aspirin;
- Common cold;
- Headache;
- Nasal congestion;
- Pharyngitis;
- Pseudoephedrine;
- Rhinomanometry;
- Sore throat pain;
- Upper respiratory tract infection;
29.Pharmacokinetics and safety of teneligliptin in subjects with hepatic impairment

机译：替尼格列汀在肝功能不全患者体内的药代动力学和安全性
- 作者：HalabiA.;MaatoukH.;SieglerK.E.;FaisstN.;HinrichsenH.
- 期刊名称：《Clinical pharmacology in drug development》 | 2014年第4期
- DPP-IV inhibitor;
- Hepatic impairment;
- MP-513;
- Pharmacokinetics;
- Teneligliptin;
30.A pharmacokinetic, pharmacodynamic, and safety study of intravenous cyclophosphamide with an oral casopitant antiemetic regimen in cancer patients

机译：口服环磷酰胺联合止吐方案对癌症患者的药代动力学，药效学和安全性研究
- 作者：AdamsL.M.;JohnsonB.;MurrayS.
- 期刊名称：《Clinical pharmacology in drug development》 | 2014年第2期
- Casopitant;
- Cyclophosphamide;
- Drug-drug interaction;
- Pharmacokinetics;
31.Pharmacokinetics and absolute bioavailability of mepolizumab following administration at subcutaneous and intramuscular sites

机译：美波珠单抗在皮下和肌肉内给药后的药代动力学和绝对生物利用度
- 作者：OrtegaH.;YanceyS.;CozensS.
- 期刊名称：《Clinical pharmacology in drug development》 | 2014年第1期
- Absorption;
- Bioavailability;
- Biologic;
- Human anti-IL5 monoclonal antibody;
- Intramuscular;
- Intravenous;
- Mepolizumab;
- Pharmacokinetics;
- Subcutaneous;
32.The ketoconazole legacy

机译：酮康唑的遗产
- 作者：GreenblattD.J.
- 期刊名称：《Clinical pharmacology in drug development》 | 2014年第1期
- Context-based complexity;
- Decision behavior;
- Decision strategies;
- Eyetracking;
- Preference measurement;
33.2014 American College of Clinical Pharmacology Annual Meeting September 14th-16th Atlanta, Georgia

机译：2014年美国临床药理学院年度会议9月14日至16日，佐治亚州亚特兰大
- 作者：Josee Michaud;Jean-Michel Paquette;Rachida Essalihi;Mira Francis;Sylvie Boily
- 期刊名称：《Clinical pharmacology in drug development》 | 2014年第1期
34.Pharmacokinetics of eicosapentaenoic acid in plasma and red blood cells after multiple oral dosing with icosapent ethyl in healthy subjects

机译：二十碳五乙酯多次口服给药后，健康受试者血浆和红细胞中二十碳五烯酸的药代动力学
- 作者：BraeckmanR.A.;StirtanW.G.;SoniP.N.
- 期刊名称：《Clinical pharmacology in drug development》 | 2014年第2期
- Eicosapentaenoic acid;
- Eicosapentaenoic acid ethyl ester;
- Fish oil;
- Hypertriglyceridemia;
- Icosapent ethyl;
- Omega-3 fatty acids;
- Pharmacokinetics;
- Triglycerides;
35.An evaluation of the systemic bioavailability of mometasone furoate (MF) after oral inhalation from a MF/formoterol fumarate metered-dose inhaler versus an MF dry-powder inhaler in healthy subjects

机译：在健康受试者中口服MF /富马酸福莫特罗计量吸入器与MF干粉吸入器口服吸入后，糠酸莫米松（MF）的全身生物利用度评估
- 作者：KosoglouT.;HubbellJ.;KantesariaB.;HansonM.E.;CutlerD.L.
- 期刊名称：《Clinical pharmacology in drug development》 | 2014年第3期
- Bioavailability;
- Dry-powder inhaler;
- Formoterol fumarate;
- Metered-dose inhaler;
- Mometasone furoate;
- Systemic exposure;
36.The effect of food on the pharmacokinetics of tivozanib hydrochloride

机译：食物对盐酸替沃扎尼药代动力学的影响
- 作者：CotreauM.M.;MassmanianL.;StrahsA.L.;SlichenmyerW.;VargoD.L.
- 期刊名称：《Clinical pharmacology in drug development》 | 2014年第2期
- Food;
- Pharmacokinetics;
- Renal cell cancer;
- Solid tumors;
- Tivozanib hydrochloride;
37.Evaluation of the effect of ruxolitinib on cardiac repolarization: A thorough QT study

机译：鲁索替尼对心脏复极的作用评估：全面的QT研究
- 作者：PunwaniN.;YeleswaramS.;ChenX.;BowmanJ.;SolovievM.;WilliamsW.
- 期刊名称：《Clinical pharmacology in drug development》 | 2014年第3期
- Clinical pharmacology;
- JAK inhibitor;
- QT prolongation;
- Ruxolitinib;
38.Pharmacokinetics and pharmacodynamics of orally administered ruxolitinib (INCB018424 phosphate) in renal and hepatic impairment patients

机译：口服鲁索替尼（INCB018424磷酸盐）在肾和肝功能不全患者中的药代动力学和药效学
- 作者：ChenX.;ShiJ.G.;EmmT.;ScherleP.A.;McgeeR.F.;LoY.;LandmanR.R.;PunwaniN.G.;WilliamsW.V.;YeleswaramS.
- 期刊名称：《Clinical pharmacology in drug development》 | 2014年第1期
- Hepatic impairment;
- Pharmacodynamics;
- Pharmacokinetics;
- Renal impairment;
- Ruxolitinib;
39.A semi-mechanistic model to characterize the pharmacokinetics and pharmacodynamics of brodalumab in healthy volunteers and subjects with psoriasis in a first-in-human single ascending dose study

机译：在首次人类单剂量研究中，半力学模型可表征溴代单抗在健康志愿者和牛皮癣患者中的药代动力学和药效学
- 作者：SalingerD.H.;EndresC.J.;MartinD.A.;GibbsM.A.
- 期刊名称：《Clinical pharmacology in drug development》 | 2014年第4期
- Brodalumab;
- Interleukin 17 receptor;
- Monoclonal antibody;
- PK/PD model;
- Psoriasis;
40.Population pharmacokinetics and safety of AZD1446, a neuronal nicotinic receptor agonist, administered in healthy volunteers

机译：在健康志愿者中施用的神经元烟碱样受体激动剂AZD1446的群体药代动力学和安全性
- 作者：Bostr?mE.;BohnstedtK.C.;JostellK.-G.;AlverlindS.;HuledalG.;PaulssonB.;H?rdemarkH.-G.;?hdJ.;LindholmS.
- 期刊名称：《Clinical pharmacology in drug development》 | 2014年第1期
- Cognition;
- Nicotinic agonist;
- NONMEM;
- Phase I;
- Population pharmacokinetics;
41.A double-blind, randomized, ascending, multiple-dose study of bazedoxifene in healthy postmenopausal women

机译：巴泽昔芬在健康绝经后妇女中的双盲，随机，递增，多剂量研究
- 作者：MckeandW.E.;OrczykG.P.;ErmerJ.C.;ChinesA.A.
- 期刊名称：《Clinical pharmacology in drug development》 | 2014年第4期
- Bazedoxifene;
- Menopause;
- Osteoporosis;
- Pharmacokinetics;
- Selective estrogen receptor modulator;
42.A Phase I cardiac safety and pharmacokinetic study of tivozanib hydrochloride in patients with advanced solid tumors

机译：盐酸替沃扎尼在晚期实体瘤患者中的I期心脏安全性和药代动力学研究
- 作者：MooreK.;InfanteJ.R.;CotreauM.M.;WilsonL.;StrahsA.L.;VargoD.L.;ChadhaM.
- 期刊名称：《Clinical pharmacology in drug development》 | 2014年第4期
- Cardiac;
- Pharmacokinetic;
- QTc;
- Solid tumor;
- Tivozanib;
43.Drug interactions with methadone: Time to revise the product label

机译：与美沙酮的药物相互作用：修改产品标签的时间
- 作者：GreenblattD.J.
- 期刊名称：《Clinical pharmacology in drug development》 | 2014年第4期
44.Evaluation of the effect of fluconazole and ketoconazole on the pharmacokinetics of tofacitinib in healthy adult subjects

机译：氟康唑和酮康唑对健康成人受试者托法替尼药代动力学的影响评估
- 作者：GuptaP.;ChowV.;WangR.;KaplanI.;ChanG.;AlveyC.;NiG.;NdongoM.-N.;LabadieR.R.;KrishnaswamiS.
- 期刊名称：《Clinical pharmacology in drug development》 | 2014年第1期
- Cytochrome P450;
- Drug-drug interactions;
- Fluconazole;
- Ketoconazole;
- Tofacitinib;
45.Rivaroxaban crushed tablet suspension characteristics and relative bioavailability in healthy adults when administered orally or via nasogastric tube

机译：口服或经鼻胃管给药时，利伐沙班压碎的片剂悬浮液特性和健康成年人的相对生物利用度
- 作者：MooreK.T.;KrookM.A.;VaidyanathanS.;SarichT.C.;DamarajuC.V.;FieldsL.E.
- 期刊名称：《Clinical pharmacology in drug development》 | 2014年第4期
- Bioavailability;
- Factor Xa inhibitor;
- Nasogastric tube;
- Pharmacokinetics;
- Rivaroxaban;
46.High-throughput screening (HTS) for the identification of novel antiviral scaffolds

机译：高通量筛选（HTS）用于鉴定新型抗病毒支架
- 作者：JadhavM.P.
- 期刊名称：《Clinical pharmacology in drug development》 | 2014年第2期
- Cardiac fibroblasts;
- Cardiac fibrosis;
- Gelatinases;
- Myocardial cells;
- Substrate stiffness;
47.Clinical pharmacology in drug development - an update

机译：药物开发中的临床药理学-最新动态
- 期刊名称：《Clinical pharmacology in drug development》 | 2015年第4期
48.Aspartame - Is there new information?

机译：阿斯巴甜-是否有新信息？
- 期刊名称：《Clinical pharmacology in drug development》 | 2015年第1期
49.Vorapaxar, an oral PAR-1 receptor antagonist, does not affect the pharmacokinetics of rosiglitazone

机译：口服PAR-1受体拮抗剂Vorapaxar不会影响罗格列酮的药代动力学
- 期刊名称：《Clinical pharmacology in drug development》 | 2015年第1期
- Clinical therapy;
- Oral antiplatelet therapy;
- Pharmacokinetics;
- Safety;
- Vorapaxar;
50.Authors' response to the letter from Dr. Srinivas.

机译：作者对Srinivas博士的信的回应。
- 作者：J Vandenbossche;H Richards;B Solanki;A Van Peer
- 期刊名称：《Clinical pharmacology in drug development》 | 2015年第6期
51.The pharmacodynamics, pharmacokinetics, safety and tolerability of inhaled fluticasone furoate and vilanterol administered alone or simultaneously as fluticasone furoate/vilanterol

机译：吸入性糠酸氟替卡松和维兰特罗单独或以氟替卡松糠酸酯/维兰特罗的形式同时给药的药效学，药代动力学，安全性和耐受性
- 期刊名称：《Clinical pharmacology in drug development》 | 2015年第1期
- Fluticasone furoate;
- Pharmacodynamics;
- Pharmacokinetics;
- Vilanterol;
52.Systemic exposure to benzoic acid and hippuric acid following topical application of clindamycin 1%/benzoyl peroxide 3% fixed-dose combination gel in Japanese patients with acne vulgaris

机译：日本寻常痤疮患者局部应用克林霉素1％/过氧化苯甲酰3％固定剂量联合凝胶后全身暴露于苯甲酸和马尿酸
- 期刊名称：《Clinical pharmacology in drug development》 | 2015年第1期
- Acne vulgaris;
- Benzoic acid;
- Benzoyl peroxide;
- Hippuric acid;
- Pharmacokinetics;
53.Safety, tolerability, and pharmacokinetics of multiple ascending doses of naloxegol.

机译：安全性，耐受性和纳洛舒尔多次递增剂量的药代动力学。
- 作者：Michael A Eldon;Alan R Kugler;Robert A Medve;Khanh Bui;Kathleen Butler;Mark Sostek
- 期刊名称：《Clinical pharmacology in drug development》 | 2015年第6期
54.Pharmacokinetic profile after multiple deltoid or gluteal intramuscular injections of paliperidone palmitate in patients with schizophrenia

机译：精神分裂症患者多次三角肌或臀肌内注射帕潘立酮棕榈酸酯后的药代动力学
- 期刊名称：《Clinical pharmacology in drug development》 | 2015年第4期
- Atypical long-acting injectable;
- Deltoid and gluteal muscle;
- Paliperidone palmitate;
- Pharmacokinetics;
- Schizophrenia;
55.A randomized, open-label 3-way crossover study to investigate the relative bioavailability and bioequivalence of crushed sildenafil 20mg tablets mixed with apple sauce, extemporaneously prepared suspension (EP), and intact sildenafil 20mg tablets in healthy volunteers under fasting conditions

机译：一项随机，开放标签的三向交叉研究，研究空腹情况下健康志愿者中西地那非20mg压碎与苹果酱，临时制备的混悬液（EP）和西地那非20mg完整片的相对生物利用度和生物等效性
- 期刊名称：《Clinical pharmacology in drug development》 | 2015年第1期
- Bioequivalence;
- Crushed tablet;
- Formulation;
- Pediatric;
- Sildenafil;
56.Assessment of relative bioavailability of two presentations of moroctocog alfa (AF-CC) in subjects with moderately severe or severe hemophilia A

机译：评估中度重度或重度A型血友病受试者中两次Mormorocog alfa（AF-CC）表现的相对生物利用度
- 期刊名称：《Clinical pharmacology in drug development》 | 2015年第3期
- Factor VIII;
- Hemophilia A;
- Moroctocog alfa;
- Pharmacokinetics;
57.The effects of the nonselective benzodiazepine lorazepam and the α2/α3 subunit-selective GABAA receptor modulators AZD7325 and AZD6280 on plasma prolactin levels

机译：非选择性苯二氮卓拉西epa和α2/α3亚基选择性GABAA受体调节剂AZD7325和AZD6280对血浆催乳素水平的影响
- 期刊名称：《Clinical pharmacology in drug development》 | 2015年第2期
- AZD6280;
- AZD7325;
- Healthy volunteers;
- Lorazepam;
- Prolactin;
58.Pharmacokinetic drug-drug interaction study of ranolazine and metformin in subjects with type 2 diabetes mellitus

机译：雷诺嗪和二甲双胍在2型糖尿病患者中的药代动力学药物相互作用研究
- 期刊名称：《Clinical pharmacology in drug development》 | 2015年第2期
- Chronic angina;
- Drug interactions;
- Metformin;
- Pharmacokinetics;
- Ranolazine;
- Type 2 diabetes mellitus;
59.PARP activity in peripheral blood lymphocytes as a predictive biomarker for PARP inhibition in tumor tissues - A population pharmacokinetic/pharmacodynamic analysis of rucaparib

机译：外周血淋巴细胞中的PARP活性是肿瘤组织中PARP抑制的预测生物标志物-rucaparib的群体药代动力学/药效学分析
- 期刊名称：《Clinical pharmacology in drug development》 | 2015年第2期
60.Inhibition of prostacyclin and thromboxane biosynthesis in healthy volunteers by single and multiple doses of acetaminophen and indomethacin

机译：单次和多次剂量对乙酰氨基酚和消炎痛对健康志愿者的前列环素和血栓烷生物合成的抑制作用
- 期刊名称：《Clinical pharmacology in drug development》 | 2015年第5期
- Acetaminophen;
- Clinical trial;
- Cyclooxygenase enzymes;
- Indomethacin;
- Urinary prostanoids;
61.Meldonium (Mildronate): A Performance-Enhancing Drug?

机译：Meldonium（Mildronate）：一种增强性能的药物？
- 作者：H Karl Greenblatt;David J Greenblatt
- 期刊名称：《Clinical pharmacology in drug development》 | 2016年第3期
62.Safety, bioavailability, and pharmacokinetics of VGX-1027-A novel oral anti-inflammatory drug in healthy human subjects.

机译：VGX-1027-A新型口服抗炎药在健康人类受试者中的安全性，生物利用度和药代动力学。
- 作者：Jessica C Lee;Stanley Menacherry;Malissa C Diehl;Mary D Giffear;C Jo White;Rob Juba;Mark L Bagarazzi;Karuppiah Muthumani;Jean Boyer;Vipin Agarwal;Ferdinando Nicoletti;Stephen Bart;J Joseph Kim;David B Weiner;Niranjan Y Sardesai
- 期刊名称：《Clinical pharmacology in drug development》 | 2016年第2期
63.The relative bioavailability of 2 prototype fixed-dose combination formulations for amlodipine and rosuvastatin in healthy white and Chinese subjects.

机译：氨氯地平和瑞舒伐他汀在健康的白人和中国受试者中的两种原型固定剂量联合制剂的相对生物利用度。
- 作者：Htar H Nwe;Jonathan N Bullman;Shashidhar M Joshi;Annie Stylianou;Shiva G Kapsi
- 期刊名称：《Clinical pharmacology in drug development》 | 2016年第2期
64.Bioequivalence of fixed-dose combinations of dapagliflozin and metformin with single-component tablets in healthy subjects and the effect of food on bioavailability.

机译：达格列净和二甲双胍固定剂量组合与单组分片剂在健康受试者中的生物等效性以及食物对生物利用度的影响。
- 作者：Tjerk W A de Bruin;Stots Reele;Jennifer E Hamer-Maansson;Shamik Parikh;Weifeng Tang
- 期刊名称：《Clinical pharmacology in drug development》 | 2016年第2期
65.Pharmacokinetics of aclidinium bromide/formoterol fumarate fixed-dose combination compared with individual components: A phase 1, open-label, single-dose study.

机译：固定剂量联合使用阿魏定溴酸盐/福莫特罗富马酸盐的药代动力学：单个阶段，开放标签，单剂量研究。
- 作者：Rainard Fuhr;Anne Leselbaum;Jordi Aubets
- 期刊名称：《Clinical pharmacology in drug development》 | 2016年第2期
66.Bioequivalence and comparative pharmacodynamics of insulin lispro 200U/mL relative to insulin lispro (Humalog?) 100U/mL

机译：赖脯胰岛素200U / mL相对于赖脯胰岛素（Humalog？）100U / mL的生物等效性和比较药效学
- 期刊名称：《Clinical pharmacology in drug development》 | 2016年第1期
- Bioequivalence;
- Diabetes mellitus;
- Insulin lispro;
- Pharmacodynamic;
- Pharmacokinetic;
67.Opicapone pharmacokinetics and pharmacodynamics comparison between healthy Japanese and matched white subjects.

机译：健康日本人和相匹配的白人受试者之间的奥匹卡帕药代动力学和药效学比较。
- 作者：Amílcar Falc?o;José Francisco Rocha;Ana Santos;Teresa Nunes;Patrício Soares-da-Silva
- 期刊名称：《Clinical pharmacology in drug development》 | 2016年第2期
68.Investigation of Drug-Drug Interactions Between Ritobegron, a Selective β3 -Adrenoceptor Agonist, With Probenecid in Healthy Men.

机译：选择性β3-肾上腺素受体激动剂Ritobegron与丙磺舒对健康男性之间药物相互作用的研究。
- 作者：Yoshikazu Abe;Yuki Nakano;Toru Kanazawa;Takao Furihata;Takuro Endo;Mamoru Kobayashi
- 期刊名称：《Clinical pharmacology in drug development》 | 2016年第3期
69.In Memoriam: David A. Flockhart, 1952-2015.

机译：纪念影片：戴维·A·弗洛克哈特（David A. Flockhart），1952-2015年。
- 作者：David J Greenblatt;Darrell R Abernethy
- 期刊名称：《Clinical pharmacology in drug development》 | 2016年第2期
70.Safety, pharmacokinetics, and pharmacodynamics of PD 0348292, an oral, direct factor Xa inhibitor, after single and multiple dosings in healthy subjects

机译：在健康受试者中单次或多次给药后，口服直接Xa因子抑制剂PD 0348292的安全性，药代动力学和药效学
- 期刊名称：《Clinical pharmacology in drug development》 | 2016年第1期
- Factor Xa;
- PD 0348292;
- Pharmacodynamics;
- Pharmacokinetics;
- Safety;
- Tolerability;
71.Pharmacokinetics of the Long-Acting Basal Insulin LY2605541 in Subjects With Varying Degrees of Renal Function.

机译：长效基础胰岛素LY2605541在不同程度肾功能患者中的药代动力学。
- 作者：Helle Linnebjerg;Siak Leng Choi;Eric Chen Quin Lam;Kenneth F Mace;Teri S Hodgson;Vikram P Sinha
- 期刊名称：《Clinical pharmacology in drug development》 | 2016年第3期
72.Pharmacokinetics, Safety, and Tolerability of Once-Daily Intranasal Fluticasone Furoate and Levocabastine Administered Alone or Simultaneously as fluticasone Furoate/Levocabastine Fixed-Dose Combination.

机译：每日一次鼻内注射氟替卡松富氟酸和Levocabastine的药代动力学，安全性和耐受性单独或同时作为氟替卡松富尿酸/ Levocabastine固定剂量联合给药。
- 作者：Ann Allen;Robert D Murdoch;Philippe Bareille;Olivia Burns;Stephen Hughes;Ashutosh Gupta;Sam R Miller
- 期刊名称：《Clinical pharmacology in drug development》 | 2016年第3期
73.Relative bioavailability of diclofenac potassium from softgel capsule versus powder for oral solution and immediate-release tablet formulation

机译：软胶囊胶囊中双氯芬酸钾相对于口服溶液和速释片剂制剂的相对生物利用度
- 作者：NovartisInstitutesforBiomedicalResearchHyderabad;NovartisInstitutesforBiomedicalResearchCambridge;NovartisPharmaCoBeijing;NovartisInstitutesforBiomedicalResearchBasel;NovartisPharmaceuticalsEastHanover;NovartisInstitutesforBiomedicalResearchEastHanover
- 期刊名称：《Clinical pharmacology in drug development》 | 2016年第1期
- Diclofenac potassium;
- Pharmacokinetics;
- Soft gelatin capsule;
74.Effects of Renal Impairment and Hepatic Impairment on the Pharmacokinetics of Hydrocodone After Administration of a Hydrocodone Extended-Release Tablet Formulated With Abuse-Deterrence Technology.

机译：施用滥用抑制技术的氢可酮缓释片给药后，肾功能不全和肝功能不全对氢可酮药代动力学的影响。
- 作者：Mona Darwish;Ronghua Yang;William Tracewell;Philmore Robertson;Mary Bond
- 期刊名称：《Clinical pharmacology in drug development》 | 2016年第2期
75.Tolerability, safety, and pharmacokinetics of the novel cathepsin A inhibitor SAR164653 in healthy subjects

机译：新型组织蛋白酶A抑制剂SAR164653在健康受试者中的耐受性，安全性和药代动力学
- 作者：Sanofi-AventisDeutschlandFrankfurta.M;HamburgUniversityMedicalCenterMetabolicLaboratory;SanofiChilly-Mazarin
- 期刊名称：《Clinical pharmacology in drug development》 | 2016年第1期
- Cathepsin A;
- First-in-man;
- Healthy subjects;
- Renal kallikrein-kinin system;
- ?-galactosidase;
76.A Phase 1, Randomized, Single-Dose Crossover Pharmacokinetic Study to Investigate the Effect of Food Intake on Absorption of Orteronel (TAK-700) in Healthy Male Subjects.

机译：一项1期，随机，单剂量交叉药代动力学研究，旨在研究食物摄入对健康男性受试者中Orteronel（TAK-700）吸收的影响。
- 作者：Ajit Suri;Theresa Pham;David B MacLean
- 期刊名称：《Clinical pharmacology in drug development》 | 2016年第3期
77.Absorption, Distribution, and Excretion of the Investigational Agent Orteronel (TAK-700) in Healthy Male Subjects: A Phase 1, Open-Label, Single-Dose Study.

机译：研究剂Orteronel（TAK-700）在健康男性受试者中的吸收，分布和排泄：阶段1，开放标签，单剂量研究。
- 作者：Ajit Suri;Sandeepraj Pusalkar;Yuexian Li;Shimoga Prakash
- 期刊名称：《Clinical pharmacology in drug development》 | 2016年第3期
78.Pharmacokinetics and pharmacodynamics of mepolizumab, an anti-interleukin 5 monoclonal antibody, in healthy Japanese male subjects.

机译：美白单抗（一种抗白介素5单克隆抗体）在健康的日本男性受试者中的药代动力学和药效学。
- 作者：Naohiro Tsukamoto;Naoki Takahashi;Hiroshi Itoh;Isabelle Pouliquen
- 期刊名称：《Clinical pharmacology in drug development》 | 2016年第2期
79.Pharmacokinetic drug-drug interaction assessment of LCZ696 (an angiotensin receptor neprilysin inhibitor) with omeprazole, metformin or levonorgestrel-ethinyl estradiol in healthy subjects

机译：LCZ696（一种血管紧张素受体中性溶酶抑制剂）与奥美拉唑，二甲双胍或左炔诺孕酮-炔雌醇的药代动力学药物-药物相互作用评估
- 期刊名称：《Clinical pharmacology in drug development》 | 2016年第1期
- Angiotensin receptor neprilysin inhibitor;
- Combination oral contraceptive;
- Drug-drug interaction;
- LCZ696;
- Metformin;
- Omeprazole;
80.Effects of Fostamatinib on the Pharmacokinetics of the CYP2C8 Substrate Pioglitazone: Results From In Vitro and Phase 1 Clinical Studies.

机译：Fostamatinib对CYP2C8底物吡格列酮的药代动力学的影响：体外和1期临床研究的结果。
- 作者：Paul Martin;Michael Gillen;David Millson;Stuart Oliver;Clive Brealey;Dominic Surry;David Sweeny;David Lau;Philip Leese
- 期刊名称：《Clinical pharmacology in drug development》 | 2016年第3期
81.Sex and Food Influence on Intestinal Absorption of Ketoprofen Gastroresistant Formulation.

机译：性别和食物对酮洛芬抗胃溃疡制剂肠道吸收的影响。
- 作者：Laura Magallanes;Marianela Lorier;Manuel Ibarra;Natalia Guevara;Marta Vázquez;Pietro Fagiolino
- 期刊名称：《Clinical pharmacology in drug development》 | 2016年第3期
82.Essential criteria for pharmacokinetic studies supporting bioequivalence of inhaled tiotropium bromide products

机译：支持吸入噻托溴铵产品生物等效性的药代动力学研究的基本标准
- 作者：BoehringerIngelheimPharmaGmbHandCo.KGIngelheimamRhein;CollegeofPharmacyUniversityofTennessee
- 期刊名称：《Clinical pharmacology in drug development》 | 2016年第1期
- Asthma;
- COPD;
- Equivalence;
- Pharmacokinetics;
- Tiotropium bromide;
83.Effect of 3 Single-Dose Regimens of Opicapone on Levodopa Pharmacokinetics, Catechol-O-Methyltransferase Activity and Motor Response in Patients With Parkinson Disease.

机译：3种单剂量奥匹卡朋方案对帕金森病患者左旋多巴的药代动力学，儿茶酚-O-甲基转移酶活性和运动反应的影响。
- 作者：José-Francisco Rocha;Joaquim J Ferreira;Amílcar Falc?o;Ana Santos;Roberto Pinto;Teresa Nunes;Luis Almeida;Patrício Soares-da-Silva
- 期刊名称：《Clinical pharmacology in drug development》 | 2016年第3期
84.Population pharmacokinetic modeling and noncompartmental analysis demonstrated bioequivalence between metformin component of metformin/vildagliptin fixed-dose combination products and metformin immediate-release tablet sourced from various countries

机译：人群药代动力学模型和非房室分析表明，二甲双胍/维达列汀固定剂量联合产品的二甲双胍成分与源自不同国家的二甲双胍速释片之间具有生物等效性
- 期刊名称：《Clinical pharmacology in drug development》 | 2016年第1期
- Bioequivalence;
- Fixed-dose combination products;
- Metformin;
- Population pharmacokinetics;
85.Perspectives in Drug Development and Clinical Pharmacology: The Discovery of Histamine H1 and H2 Antagonists

机译：药物开发和临床药理学的观点：组胺H1和H2拮抗剂的发现
- 作者：DepartmentofClinicalPharmacologyFacultyofHealthSciences
- 期刊名称：《Clinical pharmacology in drug development》 | 2016年第1期
- Allergies;
- Antihistamines;
- Drug discovery;
- Histamine antagonists;
- History;
- Hyperacidity;
- Ulcers;
86.Relative Bioavailability of a Single Dose of Belimumab Administered Subcutaneously by Prefilled Syringe or Autoinjector in Healthy Subjects.

机译：在健康受试者中，通过预填充注射器或自动注射器皮下注射单剂量Belimumab的相对生物利用度。
- 作者：Herbert Struemper;Thomas Murtaugh;Jane Gilbert;Matthew E Barton;Joseph Fire;James Groark;Norma Lynn Fox;David Roth;David Gordon
- 期刊名称：《Clinical pharmacology in drug development》 | 2016年第3期
87.Poster #088: Dose Optimization of Dichloroacetate Using a Semi- mechanistic Population Pharmacokinetic Model

机译：海报＃088：使用半机械种群药代动力学模型的二氯乙酸剂量优化
- 作者：Naveen Mangal;Albert Shroads;Taimour Langaee;Peter Stacpoole;Stephan Schmidt
- 期刊名称：《Clinical pharmacology in drug development》 | 2016年第1期
88.Single- and Multiple-Dose Pharmacokinetics of Immediate-Release/Extended-Release Ibuprofen Tablets

机译：立即释放/延长布洛芬片的单剂量和多剂量药代动力学
- 作者：Thomas Legg;Edward Paluch;Shyamalie Jayawardena
- 期刊名称：《Clinical pharmacology in drug development》 | 2017年第1期
- bioequivalence;
- ibuprofen;
- pharmacokinetics;
- absorption;
- food effect;
89.Poster #042: Echocardiographic Evaluation of Cardiotoxic Drugs: Is Ejection Fraction Adequate?

机译：海报＃042：心脏毒性药物的超声心动图评价：射血分数是否足够？
- 作者：Gerald H. Sokol;Loretta S. Loftus;Jorge Ayub;Louis Cantilena
- 期刊名称：《Clinical pharmacology in drug development》 | 2016年第1期
90.Bioavailability of Triprolidine as a Single Agent or in Combination With Pseudoephedrine: A Randomized, Open‐Label Crossover Study in Healthy Volunteers

机译：Triprolidine作为单一代理人或与伪麻黄碱组合的生物利用度：健康志愿者的随机，开放标签交叉研究
- 期刊名称：《Clinical pharmacology in drug development》 | 2020年第4期
- triprolidine hydrochloride;
- pharmacokinetics;
- bioavailability;
- cold;
- common;
- antihistamines;
- anticholinergic activity;
91.Poster #089: Development and Qualification of a Pediatric Population-based Pharmacokinetic Model for Biologics in PK-Sim~?

机译：海报＃089：PK-SIM在PK-SIM中的基于儿科人口的药代动力学模型的开发和资格〜？
- 作者：Sumit Basu;Christoph Niederalt;Haitao Yang;Yi Ting Lien;Thomas Eissing;Stephan Schmidt
- 期刊名称：《Clinical pharmacology in drug development》 | 2016年第1期
92.Issue Information

机译：发布信息
- 期刊名称：《Clinical pharmacology in drug development》 | 2017年第1期
93.A Study to Assess the Proarrhythmic Potential of Mirtazapine Using Concentration‐QTc (C‐QTc) Analysis

机译：使用浓度-QTC（C-QTC）分析评估Mirtazapine的预析电位的研究
- 作者：Gurkan Sevgi;Liu Fang;Chain Anne;Gutstein David E.
- 期刊名称：《Clinical pharmacology in drug development》 | 2019年第4期
- concentration‐QTc;
- mirtazapine;
- QTc;
- QT;
- TQT;
94.Poster #059: Placebo as Gold Standard in Randomized, Controlled Trials Based on Literature Search: Potential Confounders and Ethical Concerns

机译：海报＃059：安慰剂作为黄金标准在随机，受控试验中，基于文献搜索：潜在的混乱和伦理关注
- 作者：Charles Oo
- 期刊名称：《Clinical pharmacology in drug development》 | 2016年第1期
95.Pharmacokinetics, Food Effect, Ketoconazole Interaction, and Safety of JTK-853,a Novel Nonnucleoside HCV Polymerase Inhibitor, After Ascending Single and Multiple Doses in Healthy Subjects

机译：药代动力学，食物效果，酮康唑相互作用和JTK-853，一种新型非核苷HCV聚合酶抑制剂，在升上的单一剂量和多剂量中的健康受试者
- 作者：Sekihiro Tamaki;Tsutomu Shibata;Thomas Hunt;Barbara Gerhardt;Hiroyuki Yamada;Sudhakar M. Pai
- 期刊名称：《Clinical pharmacology in drug development》 | 2019年第3期
- first-in-human;
- genotype 1a and 1b;
- hepatitis C virus;
- JTK-853;
- nonnucleoside polymerase inhibitor;
96.Poster #060: Effects of Multiple-dose Administration of Itraconazole on the Single-dose Pharmacokinetics of Conjugated Estrogens/Bazedoxifene in Postmenopausal Women

机译：海报＃060：多剂量施用伊唑康唑对绝经后女性共轭雌激素/苯磺岛单剂药代动力学的影响
- 作者：Carol Cronenberger;Anna Plotka;Kelly Ryan;Joanne Salageanu;William McKe
- 期刊名称：《Clinical pharmacology in drug development》 | 2016年第1期
97.Population Pharmacokinetic Modeling and Probability of Target Attainment Analyses in Asian Patients With Community‐Acquired Pneumonia Treated With Ceftaroline Fosamil

机译：亚洲患有Ceftarline Fosamil治疗的亚洲患者亚洲患者的人口药代动力学建模及靶量达到概率
- 作者：Li Jianguo;Das Shampa;Zhou Diansong;Al‐Huniti Nidal
- 期刊名称：《Clinical pharmacology in drug development》 | 2019年第5期
- ceftaroline fosamil;
- community‐acquired pneumonia;
- population pharmacokinetics;
- probability of target attainment;
- PK/PD;
98.Cure Strategies for Hepatitis B Virus: The Promise of Immunotherapy

机译：治疗乙型肝炎病毒的策略：免疫疗法的承诺
- 作者：Shire Norah J.
- 期刊名称：《Clinical pharmacology in drug development》 | 2017年第1期
- HBV;
- viral hepatitis;
- anti‐PD‐1;
- anti‐PD‐L1;
- Immunotherapy;
99.Impact of Renal Impairment on the Pharmacokinetics of Apremilast and Metabolite M12

机译：肾脏损伤对阿克斯特和代谢产M12的药代动力学的影响
- 作者：Yong Liu;Simon Zhou;Mahmoud Assaf;Jim Nissel;Maria Palmisano
- 期刊名称：《Clinical pharmacology in drug development》 | 2016年第6期
- apremilast;
- kidney disease;
- phosphodiesterase 4 inhibitor;
- pharmacokinetics;
100.Theranos Experience Exposes Weaknesses in FDA Regulatory Discretion

机译：Theranos经验暴露FDA监管自由裁量权的弱点
- 作者：Jotwani Rohan;Boumil Marcia;Salem Deeb;Wetterhahn Madeline;Beninger Paul
- 期刊名称：《Clinical pharmacology in drug development》 | 2017年第1期

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