Predicting Maternal Serum Adiponectin and Leptin Level as Biomarkers of Pre-eclampsia: A Prospective Study

摘要

Background The aim of this study to determine maternal adiponectin and leptin levels as biomarkers of pre-eclampsia and compare adiponectin and leptin ratio. Materials and Methods This is a prospective study. The enrolled women were divided into two groups: frst, study group (n=60) comprised of women diagnosed with pre-eclampsia and second, control group (n=60) comprised of age- and gestation-matched normotensive and nonproteinuric women. Main Outcome Measures Maternal serum adiponectin and leptin levels and their ratio were compared in pre-eclamptic (study group) and normotensive (control group) women. Results Adiponectin levels were insignifcantly higher in study group than control group. Leptin levels in study group were signifcantly higher than control group (p23.3 ng/ml should be used as a biomarker for diagnosis. Adiponectin–leptin ratio should be considered as a biomarker for PE and should be determined in all cases of pre-eclampsia, and a cut-of of0.153 should be used for diagnosis.